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Large Injection Site Reactions After a Second Dose of Varicella Vaccine

Walter, Emmanuel B. MD, MPH; Snyder, Martha A. MD; Clements, Dennis A. MD, PhD; Katz, Samuel L. MD

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31816fc323
Brief Reports

A second dose of varicella vaccine is routinely recommended. We report 2 cases of large local reactions after receipt of a second dose of varicella vaccine administered in the thigh. The reactions resolved with symptomatic therapy. Clinicians should continue to administer the second dose of varicella vaccine, but should use the preferred site in the arm.

Author Information

From the Department of Pediatrics, Duke University Medical Center, Durham, NC.

Accepted for publication February 21, 2008.

Drs. Walter and Clements are speakers for Merck and members of Advisory Boards for Merck.

Address for correspondence: Emmanuel B. Walter, MD, MPH, Duke Children's Primary Care Clinic, 4020 N. Roxboro Rd., Durham, NC 27704. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.