Large Injection Site Reactions After a Second Dose of Varicella VaccineWalter, Emmanuel B. MD, MPH; Snyder, Martha A. MD; Clements, Dennis A. MD, PhD; Katz, Samuel L. MDPediatric Infectious Disease Journal: August 2008 - Volume 27 - Issue 8 - pp 757-759 doi: 10.1097/INF.0b013e31816fc323 Brief Reports Abstract Author Information A second dose of varicella vaccine is routinely recommended. We report 2 cases of large local reactions after receipt of a second dose of varicella vaccine administered in the thigh. The reactions resolved with symptomatic therapy. Clinicians should continue to administer the second dose of varicella vaccine, but should use the preferred site in the arm. From the Department of Pediatrics, Duke University Medical Center, Durham, NC. Accepted for publication February 21, 2008. Drs. Walter and Clements are speakers for Merck and members of Advisory Boards for Merck. Address for correspondence: Emmanuel B. Walter, MD, MPH, Duke Children's Primary Care Clinic, 4020 N. Roxboro Rd., Durham, NC 27704. E-mail: firstname.lastname@example.org. © 2008 Lippincott Williams & Wilkins, Inc.