A prospective, school-based study included daily monitoring for incidence of symptomatic streptococcal-associated pharyngitis and monthly determinations of group A streptococcal prevalence. A treatment group received penicillin/erythromycin therapy at school for positive throat cultures; the control group sought medical care from their regular provider. Prevalence and incidence of group A streptococcal pharyngitis were significantly lower among the treatment group than in the controls.
From the *Rheumatic Fever Laboratory and the Division of Epidemiology, Guangdong Provincial Cardiovascular Institute; Guangdong Provincial People's Hospital, Guangzhou, Guangdong Province, Peoples’ Republic of China; and †The World Health Organization Collaborating Center for Reference and Research on Streptococci, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
Accepted for publication February 5, 2008.
This study was supported by “The National Eighth-five Year Key Project” of the Ministry of National Science and Technology, People's Republic of China.
Address for correspondence: Edward L. Kaplan, MD, Department of Pediatrics, Mail Code 296, University of Minnesota Medical School, 420 Delaware St. SE, Minneapolis, MN 55455. E-mail: email@example.com.