Skip Navigation LinksHome > July 2008 - Volume 27 - Issue 7 > Tick-Borne Lymphadenopathy: A New Infectious Disease in Chil...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31816b1947
Original Studies

Tick-Borne Lymphadenopathy: A New Infectious Disease in Children

Porta, Ferran Segura MD, PhD*†; Nieto, Esperanza Antón MD*†; Creus, Bernat Font MD*; Espín, Tomás Muñoz MD‡; Casanova, Francisco Javier Travería MD‡; Sala, Isabel Sanfeliu MSc†§; García, Sergio Lario PhD*; Aguilar, Jesus Luelmo MD¶; Vilaseca, Mariela Quesada PhD*†

Supplemental Author Material
Collapse Box


Objective: To describe the epidemiologic and clinical aspects of patients with tick-borne lymphadenopathy (TIBOLA).

Patients and Methods: The study included all patients treated in our hospital who presented characteristic clinical signs of TIBOLA consisting in the presence of an inoculation lesion after a tick bite with regional lymphadenopathies. The study was carried out at the “Corporació Parc Taulí” hospital in the city of Sabadell, Barcelona, Spain. The inclusion period was from April 2000 to April 2006. Serology tests were performed for Rickettsia conorii, R. slovaca, and Borrelia burgdorferi. The presence of Rickettsia was assessed by means of polymerase chain reaction (PCR)-restriction fragment length polymorphism (PCR-RFLP) and linear-after-the exponential-PCR in blood, skin biopsy, and ticks from the patients.

Results: Thirty-six patients fulfilled the inclusion criteria. Twenty-eight patients were children. In most cases, infection occurred between the months of October and April. In 34 patients the tick bite was on the scalp. A necrotic eschar surrounded by a perilesional erythematous halo was observed in 29 cases. All patients had painful regional lymphadenopathies. Serology for R. conorii was positive in 8 cases and for R. slovaca in 2. PCR was negative.

The tick, identified as Dermacentor marginatus, was studied in 7 patients. Four of the 7 D. marginatus were positive for sequences compatible with R. slovoca as determined by RFLP or DNA sequencing. Thirty-three patients received antibiotic treatment. Progress was satisfactory in all cases.

Conclusions: TIBOLA is present in Catalonia (Northeastern Spain) mainly in children. Although clinical and epidemiologic manifestations are very specific microbiologic confirmation is difficult.

© 2008 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.