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Immunogenicity and Safety of an Inactivated Hepatitis A Vaccine Administered Concomitantly With a Pneumococcal Conjugate Vaccine in Healthy Children 15 Months of Age

Trofa, Andrew F. MD, FACP*; Levin, Michael MD, MPH†; Marchant, Colin D. MD‡§; Hedrick, James MD¶; Blatter, Mark M. MD∥

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31816907bd
Brief Reports
Abstract

The immunogenicity and safety of hepatitis A vaccine and pneumococcal conjugate vaccine, administered separately or concomitantly in children 15 months of age, were evaluated. After completed vaccinations, antihepatitis A and antipneumococcal geometric mean concentrations were similar across groups. Both vaccines were well-tolerated when given concomitantly during the second year of life.

Author Information

From the *Department of Clinical Research, Development, and Medical Affairs, Vaccines for Viral Diseases, GlaxoSmithKline, King of Prussia, PA; †Henderson Pediatrics, Henderson, NV; ‡Boston University School of Boston, §Tufts University School of Medicine, Boston, MA; ¶Kentucky Pediatric and Adult Research, Bardstown, KY; and ∥Primary Physicians Research, Pittsburgh, PA.

Accepted for publication January 15, 2008.

This study was funded by GlaxoSmithKline Biologicals.

Address for correspondence: Andrew F. Trofa, MD, FACP, GlaxoSmithKline, Department of Clinical Research, Development, and Medical Affairs, 2301 Renaissance Boulevard, RN 0220, King of Prussia, PA 19406.

© 2008 Lippincott Williams & Wilkins, Inc.