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Efficacy of Pentavalent Human-Bovine (WC3) Reassortant Rotavirus Vaccine Based on Breastfeeding Frequency

Goveia, Michelle G. MD, MPH; DiNubile, Mark J. MD; Dallas, Michael J. PhD; Heaton, Penny M. MD; Kuter, Barbara J. PhD, MPH; for the REST Study Team

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318168d29e
Brief Reports
Abstract

The efficacy of a live, oral, pentavalent rotavirus vaccine against G1-4 rotavirus gastroenteritis (RVGE) was retrospectively assessed based on breastfeeding frequency among 5098 infants in a placebo-controlled trial. The efficacy against any RVGE severity for infants never breastfed, sometimes breastfed, or exclusively breastfed was 68.3%, 82.2%, and 68.0%, respectively. The efficacy against severe RVGE was 100%, 95.4%, and 100%, respectively. Breastfeeding did not seem to adversely impact the efficacy of pentavalent rotavirus vaccine.

Author Information

From Merck & Co., Inc., West Point, PA.

Accepted for publication January 14, 2008.

This study was sponsored and supported by Merck & Co., Inc.

Address for correspondence: Barbara J. Kuter, PhD, MPH, Merck & Co., Inc, PO Box 4, West Point, PA 19486. E-mail: barbara_kuter@merck.com.

© 2008 Lippincott Williams & Wilkins, Inc.