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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181694fcf
Instructive Cases

Acute Encephalopathy With Human Parvovirus B19 Infection in Hereditary Spherocytosis

Oshima, Koichi MD*†; Kikuchi, Akira MD*; Mochizuki, Shinji MD*; Arai, Takashi†; Oishi, Tsutomu MD†; Hanada, Ryoji MD*

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A 9-year-old girl with hereditary spherocytosis developed aplastic crisis and encephalopathy associated with human parvovirus B19 (PVB19) infection. During the clinical course, we followed PVB19 DNA in her plasma and cerebrospinal fluid by real-time polymerase chain reaction and found that her symptoms of encephalopathy had occurred at the peak viral load. PVB19-associated encephalopathy might occur as a result of direct invasion by PVB19.

© 2008 Lippincott Williams & Wilkins, Inc.


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