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Acute Encephalopathy With Human Parvovirus B19 Infection in Hereditary Spherocytosis

Oshima, Koichi MD*†; Kikuchi, Akira MD*; Mochizuki, Shinji MD*; Arai, Takashi†; Oishi, Tsutomu MD†; Hanada, Ryoji MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181694fcf
Instructive Cases

A 9-year-old girl with hereditary spherocytosis developed aplastic crisis and encephalopathy associated with human parvovirus B19 (PVB19) infection. During the clinical course, we followed PVB19 DNA in her plasma and cerebrospinal fluid by real-time polymerase chain reaction and found that her symptoms of encephalopathy had occurred at the peak viral load. PVB19-associated encephalopathy might occur as a result of direct invasion by PVB19.

Author Information

From the *Division of Hematology/Oncology; and †Laboratory of Clinical Research, Saitama Children's Medical Center, Saimata, Japan.

Accepted for publication January 17, 2008.

Address for correspondence: Koichi Oshima, MD, Division of Hematology/Oncology, Saitama Children's Medical Center, 2100 Magome, Iwatsuki-ku, Saitama 339-8551, Japan. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.