Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.
From the *Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD; †Center for Global Child Health, Cincinnati Children's Hospital, Cincinnati, OH; ‡Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Division of Epidemiology, Vaccine Safety Branch, Rockville, MD; §Centers for Disease Control and Prevention, Atlanta, GA; and ∥Department of Pediatrics, Pediatric Clinical Research Office, Vanderbilt University School of Medicine, Nashville, TN.
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Accepted for publication December 17, 2007.
Supported by the Centers for Disease Control and Prevention (200-20002-00732) through America's Health Insurance Plans.
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Address for correspondence: Kathryn Edwards, MD, Professor of Pediatrics, CCC-5323 Medical Center North, Vanderbilt University, Nashville, TN 37232. E-mail: email@example.com.