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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31816591f7
Brief Reports

Safety of A Fifth Dose of Diphtheria and Tetanus Toxoid and Acellular Pertussis Vaccine in Children Experiencing Extensive, Local Reactions to the Fourth Dose

Rennels, Margaret B. MD*; Black, Steven MD†; Woo, Emily Jane MD, MPH‡; Campbell, Scott MPH§; Edwards, Kathryn M. MD∥

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Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.

© 2008 Lippincott Williams & Wilkins, Inc.


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