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SAFETY OF A FIFTH DOSE OF DIPHTHERIA AND TETANUS TOXOID AND ACELLULAR PERTUSSIS VACCINE IN CHILDREN EXPERIENCING EXTENSIVE, LOCAL REACTIONS TO THE FOURTH DOSE

Rennels, Margaret B. MD*; Black, Steven MD†; Woo, Emily Jane MD, MPH‡; Campbell, Scott MPH§; Edwards, Kathryn M. MD∥

Pediatric Infectious Disease Journal: May 2008 - Volume 27 - Issue 5 - pp 464-465
doi: 10.1097/INF.0b013e31816591f7
Brief Reports

Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.

From the *Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD; †Center for Global Child Health, Cincinnati Children's Hospital, Cincinnati, OH; ‡Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Division of Epidemiology, Vaccine Safety Branch, Rockville, MD; §Centers for Disease Control and Prevention, Atlanta, GA; and ∥Department of Pediatrics, Pediatric Clinical Research Office, Vanderbilt University School of Medicine, Nashville, TN.

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Accepted for publication December 17, 2007.

Supported by the Centers for Disease Control and Prevention (200-20002-00732) through America's Health Insurance Plans.

The content of this publication does not necessarily reflect the views or politics of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Address for correspondence: Kathryn Edwards, MD, Professor of Pediatrics, CCC-5323 Medical Center North, Vanderbilt University, Nashville, TN 37232. E-mail: kathryn.edwards@vanderbilt.edu.

© 2008 Lippincott Williams & Wilkins, Inc.