Skip Navigation LinksHome > January 2008 - Volume 27 - Issue 1 > RANDOMIZED, CONTROLLED TRIAL EFFICACY OF PNEUMOCOCCAL CONJUG...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318159228f
Brief Reports

RANDOMIZED, CONTROLLED TRIAL EFFICACY OF PNEUMOCOCCAL CONJUGATE VACCINE AGAINST OTITIS MEDIA AMONG NAVAJO AND WHITE MOUNTAIN APACHE INFANTS

O’Brien, Katherine L. MD, MPH; David, Angeline B. MHS; Chandran, Aruna MD, MPH; Moulton, Lawrence H. PhD; Reid, Raymond MD, MPH; Weatherholtz, Robert BS; Santosham, Mathuram MD, MPH

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Abstract

We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. Efficacy was −0.4% (95% CI: −19.4 to 15.6) for clinically-diagnosed OM, 5.1% (95% CI: −51.5 to 40.6) for severe OM, and 64% (95% CI: −34% to 90%) for vaccine serotype pneumococcal OM suggesting that this vaccine is efficacious for pneumococcal OM in this high risk population.

© 2008 Lippincott Williams & Wilkins, Inc.

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