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Similarities of Kawasaki Disease and Yersinia pseudotuberculosis Infection Epidemiology

Vincent, Pascal MD*; Salo, Eeva MD†; Skurnik, Mikael PhD‡; Fukushima, Hiroshi MDV§; Simonet, Michel PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3180616d3c
Opinion and Analysis

Although an infectious etiology is strongly suspected in Kawasaki disease (KD), an etiologic agent has not yet been identified. By reviewing epidemiologic data published in past decades, this work highlights a higher incidence of KD when populations were exposed to the risk of Yersinia pseudotuberculosis infection. This hitherto unnoticed element reinforces the hypothesis whereby this bacterium might contribute to the development of KD in some cases.

Author Information

From the *Faculté de médecine Henri Warembourg and Institut Pasteur, Lille, France; †Hospital for Children and Adolescents, University of Helsinki, Finland; ‡Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland; and §Shimane Prefectural Institute of Public Health and Environmental Science, Matsue, Shimane, Japan.

Accepted for publication March 22, 2007.

Address for correspondence: Pascal Vincent, MD, Service de Bactériologie-Hygiène, Hôpital Calmette/CHRU de Lille, 1 bd du Pr J. Leclercq, F-59 037 Lille Cedex. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.