Skip Navigation LinksHome > June 2007 - Volume 26 - Issue 6 > MATRIX METALLOPROTEINASE-9 AND TISSUE INHIBITORS OF METALLOP...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31803994a0
Brief Reports

MATRIX METALLOPROTEINASE-9 AND TISSUE INHIBITORS OF METALLOPROTEINASES 1 IN INFLUENZA-ASSOCIATED ENCEPHALOPATHY

Ichiyama, Takashi MD*; Morishima, Tsuneo MD†; Kajimoto, Madoka MD*; Matsushige, Takeshi MD*; Matsubara, Tomoyo MD*; Furukawa, Susumu MD*

Collapse Box

Abstract

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood–brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood–brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.

© 2007 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.