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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31803994a0
Brief Reports

Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinases 1 in Influenza-Associated Encephalopathy

Ichiyama, Takashi MD*; Morishima, Tsuneo MD†; Kajimoto, Madoka MD*; Matsushige, Takeshi MD*; Matsubara, Tomoyo MD*; Furukawa, Susumu MD*

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Abstract

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood–brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood–brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.

© 2007 Lippincott Williams & Wilkins, Inc.

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