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Ichiyama, Takashi MD*; Morishima, Tsuneo MD†; Kajimoto, Madoka MD*; Matsushige, Takeshi MD*; Matsubara, Tomoyo MD*; Furukawa, Susumu MD*
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood–brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood–brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.
© 2007 Lippincott Williams & Wilkins, Inc.
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Epstein-Barr virus, influenza-associated encephalopathy, MMP-9, respiratory syncytial virus, TIMP-1
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