Active, population-based surveillance for invasive pneumococcal infections in Greater Vancouver (population 473,000 children) demonstrated a rapid, substantial decrease in incidence rates for children 6–23 months old with routine infant vaccination. In the subpopulation with best case ascertainment disease rates for 6–23 month olds decreased 84.6% (92.5% for vaccine serotypes).
From the *Vaccine Evaluation Center, BC Children's Hospital, Vancouver; †BC Centre for Disease Control, Vancouver; ‡Fraser Health Authority, Surrey; §Vancouver-Coastal Health Authority, Vancouver, British Columbia; and the ∥National Centre for Streptococcus, Edmonton, Alberta, Canada.
Accepted for publication January 23, 2007.
Supported by a grant from Wyeth Pharmaceuticals Canada, Markham, Ontario.
Presented in brief at the 7th Canadian Immunization Conference, Winnipeg, Manitoba, December 3–6, 2006 (abstract P01).
Address for correspondence: David Scheifele, MD, Vaccine Evaluation Center, Room L427–4500 Oak Street, Vancouver, B.C., Canada V6H 3N1. E-mail: firstname.lastname@example.org.