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SERUM ANTIBODIES TO THE PNEUMOCOCCAL SURFACE PROTEINS PhtB AND PhtE IN FINNISH INFANTS AND ADULTS

Holmlund, Emma MSc*; Simell, Birgit PhD*; Jaakkola, Teija*; Lahdenkari, Mika MSc*; Hamel, Josée PhD†; Brodeur, Bernard PhD†; Kilpi, Terhi MD, PhD*; Käyhty, Helena PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000261198.90649.04
Brief Reports
Abstract

We examined naturally acquired antibodies to pneumococcal vaccine candidate proteins PhtB and PhtE in children during their first 2 years of life. Prior culture-confirmed pneumococcal exposure was shown to induce the development of anti-PhtB and -PhtE antibodies. The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media.

Author Information

From the *The National Public Health Institute, Helsinki, Finland; and †Laval University, Quebec, Canada.

Accepted for publication February 2, 2007.

Address for correspondence: Birgit Simell, PhD, National Public Health Institute, Department of Vaccines, Mannerheimintie 166, Helsinki, Finland. E-mail: birgit.simell@ktl.fi.

© 2007 Lippincott Williams & Wilkins, Inc.