We examined naturally acquired antibodies to pneumococcal vaccine candidate proteins PhtB and PhtE in children during their first 2 years of life. Prior culture-confirmed pneumococcal exposure was shown to induce the development of anti-PhtB and -PhtE antibodies. The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media.
From the *The National Public Health Institute, Helsinki, Finland; and †Laval University, Quebec, Canada.
Accepted for publication February 2, 2007.
Address for correspondence: Birgit Simell, PhD, National Public Health Institute, Department of Vaccines, Mannerheimintie 166, Helsinki, Finland. E-mail: email@example.com.