Skip Navigation LinksHome > May 2006 - Volume 25 - Issue 5 > The Epidemiology of Haemophilus influenzae Type b Meningitis...
Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000217371.38080.8a
Original Studies

The Epidemiology of Haemophilus influenzae Type b Meningitis in Burkina Faso

Yaro, Seydou MD*; Lourd, Mathilde MPH†; Naccro, B MD; for the Clinical Group; Njanpop-Lafourcade, Berthe-Marie PhD†; Hien, Alain PharmD; for the Laboratory Group; Ouedraogo, Macaire S. MD†; Traore, Yves PhD§; Schouls, Leo M. PhD∥; du Châtelet, Isabelle Parent MD†; Gessner, Bradford D. MD†

Collapse Box


Background: Haemophilus influenzae type b (Hib) disease burden studies are important to conduct in African countries that plan to introduce vaccine so that vaccine impact can be documented.

Methods: We implemented population-based meningitis surveillance in 3 districts of Burkina Faso for 12 months each during 2002–2003 and 2004–2005 using polymerase chain reaction, culture and antigen detection.

Results: Lumbar puncture was performed on 1686 patients and 112 had Hib identified. Persons <1, <5, 5–14 and 15+ years of age had annual Hib meningitis incidences of 97, 34, 2.1 and 0.55 per 100,000, respectively; overall case fatality proportion was 25%. During the historic meningitis epidemic season months of December through April, the proportion of purulent cerebrospinal fluid among children aged <5 years that yielded Hib was 27% compared with 30% during other months. Twenty-five of 98 persons with information available were treated with only one or 2 doses of oily chloramphenicol. Among children age <5 years with Hib meningitis, 28% were pretreated with antimalarials and antimalarial pretreatment was associated with delay in hospitalization.

Conclusions: In Burkina Faso, Hib meningitis incidence and case fatality proportion are high and thus vaccine could have a substantial impact. While awaiting well-implemented routine infant Hib vaccination, empiric case management for pediatric meningitis in sub-Saharan Africa must recognize that Hib is likely even during the epidemic season. In malaria-endemic areas, pediatric Hib meningitis case management may be adversely affected by the similar presentation of these 2 diseases.

© 2006 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.