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Pharmacokinetics of Rifapentine in Children

Blake, Michael J. MD, PhD*†; Abdel-Rahman, Susan M. PharmD*†; Jacobs, Richard F. MD‡§; Lowery, Nancy K. RN, CCRC∥; Sterling, Timothy R. MD¶; Kearns, Gregory L. PharmD, PhD*†#

Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000214963.55217.9c
Original Studies
Abstract

Background: Rifapentine is a rifamycin antibiotic approved for the treatment of pulmonary infections caused by Mycobacterium tuberculosis. Although the pharmacokinetics of rifapentine has been investigated in adolescents and adults, no studies have assessed the pharmacokinetics of this drug in children or infants.

Methods: Twenty-four children (7.1 ± 3.3 years; mean ± 1 SD, 27.9 ± 11.9 kg) were enrolled in this open label study. Children received a single oral dose (10 to <30 kg body weight received 150 mg; 30 to <60 kg body weight received 300 mg), followed by repeated blood sampling (n = 11) for 32 hours. Rifapentine and 25-desacetyl rifapentine were quantitated by a validated high-pressure liquid chromatography method. Pharmacokinetic parameters were determined using a model-independent approach.

Results: A significant difference in dose-normalized area under the curves (AUC0–n and AUC0–∞) was observed between children receiving the 150 and 300 mg doses, which was accounted for by differences in age between the dosing arms. In separate analyses, including data from adults, further age-dependence in total body exposure (reflected by AUC) and elimination was observed. Adverse events associated with rifapentine were mild and included gastric distress (n = 1) and vomiting (n = 2).

Conclusions: Given a comparable weight-normalized dose, rifapentine exposure estimates are lower in children than those reported in adults, suggesting that a larger weight-normalized (ie, mg/kg) dose of rifapentine is needed in children.

Author Information

From the *Department of Pediatrics, University of Missouri–Kansas City, School of Medicine, the †Division of Pediatric Pharmacology and Medical Toxicology, Children's Mercy Hospitals and Clinics, Kansas City, Missouri; the ‡Department of Pediatrics, University of Arkansas for Medical Sciences, §Divisions of Infectious Disease and ∥Clinical Pharmacology and Toxicology, Arkansas Children's Hospital, Little Rock, Arkansas, ¶Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, the #Department of Pharmacology, University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri

Accepted for publication November 23, 2005.

Supported, in part, by grants 5 U10 HD31313-12 (Network of Pediatric Pharmacology Research Units) (G.L.K.), 1 F32 HD043625-01 (M.J.B.), National Institute of Child Health and Human Development, Bethesda, Maryland, and the Centers for Disease Control and Prevention–Tuberculosis Trials Consortium.

Address for correspondence: Gregory L. Kearns, PharmD, PhD, Chief, Division of Pediatric Pharmacology and Medical Toxicology, The Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108; Fax 816-855-1958; E-mail gkearns@cmh.edu.

© 2006 Lippincott Williams & Wilkins, Inc.