Skip Navigation LinksHome > May 2006 - Volume 25 - Issue 5 > COMPLEX CLONAL FEATURES IN AN MYCOBACTERIUM TUBERCULOSIS INF...
Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000217473.90673.00
Brief Reports

COMPLEX CLONAL FEATURES IN AN MYCOBACTERIUM TUBERCULOSIS INFECTION IN A TWO-YEAR-OLD CHILD

de Viedma, Darío García PhD; Marín, Mercedes PhD; Andrés, Sandra; Lorenzo, Gema PhD; Ruiz-Serrano, María Jesús; Bouza, Emilio MD, PhD

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Abstract

The focus of this report is to describe the highly complex clonal features of the Mycobacterium tuberculosis (MTB) isolates cultured from a 2-year-old child with no risk factors for tuberculosis. Molecular analysis showed that she was coinfected by 2 MTB isolates. The coinfecting isolates showed only subtle genetic differences and shared equivalent infectivity in vitro; however, they were infecting independent anatomic sites (compartmentalized infection). One of the MTB isolates was cultured only from respiratory specimens, whereas the other was isolated from extrarespiratory site (central nervous system).

© 2006 Lippincott Williams & Wilkins, Inc.

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