You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

LOW IMMUNOLOGIC RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN NAIVE VERTICALLY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1-INFECTED CHILDREN WITH SEVERE IMMUNODEFICIENCY

Resino, Salvador PhD*; Alvaro-Meca, Alejandro MSc*; de José, Maria Isabel MD‡; Martin-Fontelos, Pablo MD§; Gutiérrez, Maria Dolores Gurbindo MD†; Léon, Juan Antonio MD∥; Ramos, José Tomás MD¶; Ciria, Luis MD#; Muñoz-Fernández, Maria Ángeles PhD*,1

Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000207419.50016.5e
Brief Reports
Abstract

We conducted a retrospective study to analyze the CD4+ recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4+ of <15% did not reach a mean CD4+ of ≥25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4+.

Author Information

From the *Laboratorio de Inmuno-Biología Molecular and †Inmuno-Pediatría, Hospital General Universitario “Gregorio Marañón,” Madrid; ‡Inmuno-Pediatría, Hospital Universitario “La Paz,” Madrid; §Pediatría-Infecciosas, Hospital Universitario “Carlos III,” Madrid; ∥Pediatría-Infecciosas, Hospital Universitario “Virgen de Rocío,” Seville; ¶Inmuno-Pediatría, Hospital Universitario “12 de Octubre,” Madrid; and #Pediatría-Infecciosas; Hospital Universitario “Niño Jesús,” Madrid, Spain

Accepted for publication November 23, 2005.

Supported by Fundación para la Investigación y la Prevención del SIDA en España, FIPSE (grant 12456/03), Fundación para la Investigación Sanitaria (FIS) del Ministerio de Sanidad y Consumo (PI040883, PI052479, PI052472, PI052411), Plan Nacional de Salud (SAF 2003-09209, SAF-2004-06778), Red Temática Cooperativa de investigación en SIDA (RIS G03/173) of FIS, and Red Temática Cooperativa de investigación en Genética (RIG C03/07). Dr Resino received a staff research grant from FIS (CP04/00090).

E-mail sresino.hgugm@salud.madrid.org. Reprints not available.

© 2006 Lippincott Williams & Wilkins, Inc.