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Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000207419.50016.5e
Brief Reports

LOW IMMUNOLOGIC RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN NAIVE VERTICALLY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1-INFECTED CHILDREN WITH SEVERE IMMUNODEFICIENCY

Resino, Salvador PhD*; Alvaro-Meca, Alejandro MSc*; de José, Maria Isabel MD‡; Martin-Fontelos, Pablo MD§; Gutiérrez, Maria Dolores Gurbindo MD†; Léon, Juan Antonio MD∥; Ramos, José Tomás MD¶; Ciria, Luis MD#; Muñoz-Fernández, Maria Ángeles PhD*,1

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Abstract

We conducted a retrospective study to analyze the CD4+ recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4+ of <15% did not reach a mean CD4+ of ≥25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4+.

© 2006 Lippincott Williams & Wilkins, Inc.

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