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Investigation of Treatment Failure in Neonatal Echovirus 7 Infection

Rentz, Alison C. MD*; Libbey, Jane E. MS†; Fujinami, Robert S. PhD†; Whitby, Frank G. PhD‡; Byington, Carrie L. MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/01.inf.0000202071.38484.93
Instructive Cases
Abstract

We describe a case of fatal neonatal enteroviral infection caused by echovirus 7. Multiple treatments, including specific antiviral therapy, were attempted and failed. Studies of the viral isolate, maternal plasma, intravenous immunoglobulin preparations and pleconaril were performed to identify potential causes for treatment failure.

Author Information

From the Departments of *Pediatrics, †Neurology and ‡Biochemistry, University of Utah School of Medicine, Salt Lake City, UT

Accepted for publication November 11, 2005.

Dr Rentz was supported in part by the Children's Health Research Center, University of Utah and was a Primary Children's Medical Center Foundation Scholar. Dr Fujinami was supported by National Institutes of Health grant IH NS 034497.

Dr Rentz and Ms Libbey made equal scientific contributions to the study.

Figures 1, 2 and 3 are available on line at the journal website, www.pidj.com

E-mail alison.rentz@childrens.harvard.edu. Reprints not available.

© 2006 Lippincott Williams & Wilkins, Inc.