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Pediatric Infectious Disease Journal:
Instructive Cases

Interferon-γ and Colony-Stimulating Factors as Adjuvant Therapy for Refractory Fungal Infections in Children

Abzug, Mark J. MD*; Walsh, Thomas J. MD†

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Abstract

A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

© 2004 Lippincott Williams & Wilkins, Inc.

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