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Interferon-γ and Colony-Stimulating Factors as Adjuvant Therapy for Refractory Fungal Infections in Children

Abzug, Mark J. MD*; Walsh, Thomas J. MD†

Pediatric Infectious Disease Journal: August 2004 - Volume 23 - Issue 8 - pp 769-773
Instructive Cases

A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

From the *University of Colorado School of Medicine and The Children’s Hospital (Pediatric Infectious Diseases, Department of Pediatrics), Denver, CO; and †National Cancer Institute (Immunocompromised Host Section, Pediatric Oncology Branch), Bethesda, MD

Accepted for publication April 21, 2004.

Address for reprints: Mark J. Abzug, MD, Pediatric Infectious Diseases, Box B055, The Children’s Hospital, 1056 East 19th Avenue, Denver, CO 80218. Fax 303-837-2707; E-mail abzug.mark@tchden.org.

© 2004 Lippincott Williams & Wilkins, Inc.