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Fungal Biofilm Formation on Cochlear Implant Hardware After Antibiotic-Induced Fungal Overgrowth Within the Middle Ear

Cristobal, Ricardo MD, PhD*; Edmiston, Charles E. Jr. PhD†; Runge-Samuelson, Christina L. PhD*; Owen, Heather A. PhD‡; Firszt, Jill B. PhD*; Wackym, P. Ashley MD, FACS*

Pediatric Infectious Disease Journal:
Instructive Cases

Cochlear implantation in patients with chronic suppurative otitis media is managed with perioperative antibiotics; however, fungal overgrowth can occur. We present a child who received oral cefdinir and topical ofloxacin (Floxin). After 6 weeks, a fungal (Candida) biofilm was demonstrated on the implant surface. In this clinical setting, an antimicrobial strategy using an oral antifungal to prevent fungal overgrowth is a possibility.

Author Information

From the Departments of *Otolaryngology and Communication Sciences and ‡Biological Sciences, University of Wisconsin, Milwaukee, Milwaukee, WI †Surgery, Medical College of Wisconsin, Milwaukee, WI

Supported by intramural funds from the Toohill Research Fund of the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin.

Accepted for publication April 1, 2004.

Address for reprints: P. Ashley Wackym, MD, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226-3596. Fax 414-266-6989; E-mail

© 2004 Lippincott Williams & Wilkins, Inc.