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SAFETY OF MEFLOQUINE IN INFANTS WITH ACUTE FALCIPARUM MALARIA

Dubos, François MD†; Delattre, Pierre MD†; Demar, Magali MD‡; Carme, Bernard MD‡; Gendrel, Dominique MD§

Pediatric Infectious Disease Journal: July 2004 - Volume 23 - Issue 7 - pp 679-681
Brief Reports

We evaluated retrospectively the safety of mefloquine (25 mg/kg) for the curative treatment of uncomplicated Plasmodium falciparum malaria in 26 infants weighing <15 kg and managed during a 5-year period. Side effects were recorded in 30.8% of patients and consisted chiefly of mild and transient gastrointestinal symptoms. Mefloquine was safe in infants weighing <15 kg in our experience.

From the Pediatric Intensive Care Unit, Jeanne de Flandre Hospital, Lille, France; the †Pediatrics Department, Andrée Rosemon Hospital, Cayenne, France; the ‡Parasitology-Mycology Laboratory, Cayenne Teaching Hospital and Antilles Guyana Teaching and Research Center, Cayenne, France; and the §Pediatrics Department, Saint Vincent de Paul Teaching Hospital, Paris, France

Accepted for publication February 13, 2004.

Address for reprints: Francçois Dubos, MD, Service de Réanimation Pédiatrique, Hôpital Jeanne de Flandre, 2 avenue Oscar Lambret, 59 037 Lille Cedex, France. Fax +33 3 20 44 60 83; E-mail frandubos@wanadoo.fr

© 2004 Lippincott Williams & Wilkins, Inc.