To assess whether pertussis-containing vaccines cause encephalitis or encephalopathy, the IMPACT network of Canadian pediatric centers screened more than 12,000 admissions for neurologic disorders between 1993 and 2002. Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine.
From the *Montreal Children’s Hospital, McGill University Health Centre, Quebec, Canada; the †Department of Pediatrics, University of Ottawa, Ottawa, Canada; ‡British Columbia’s Children’s Hospital, Vancouver, British Columbia, Canada; and §IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Supported by the Division of Immunization and Respiratory Diseases, Centre for Infectious Disease Prevention and Control, Health Canada, Ottawa and administered by the Canadian Paediatric Society, Ottawa.
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