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Lack of Evidence of Encephalopathy Related to Pertussis Vaccine : Active Surveillance by IMPACT, Canada, 19932002

Moore, Dorothy L. MD, PhD*; Le Saux, Nicole MD†; Scheifele, David MD‡; Halperin, Scott A. MD§; Members of the Canadian Paediatric Society/Health Canada Immunization Monitoring Program Active (IMPACT)

Pediatric Infectious Disease Journal:
Brief Reports

To assess whether pertussis-containing vaccines cause encephalitis or encephalopathy, the IMPACT network of Canadian pediatric centers screened more than 12,000 admissions for neurologic disorders between 1993 and 2002. Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine.

Author Information

From the *Montreal Children’s Hospital, McGill University Health Centre, Quebec, Canada; the †Department of Pediatrics, University of Ottawa, Ottawa, Canada; ‡British Columbia’s Children’s Hospital, Vancouver, British Columbia, Canada; and §IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada

Supported by the Division of Immunization and Respiratory Diseases, Centre for Infectious Disease Prevention and Control, Health Canada, Ottawa and administered by the Canadian Paediatric Society, Ottawa.

Address for reprints: Dorothy L. Moore, Room C1242, Montreal Children’s Hospital, 2300 rue Tupper, Montreal, Quebec, Canada H3H 1P3. Fax 514-412-4494; E-mail

© 2004 Lippincott Williams & Wilkins, Inc.