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Immunogenicity of Inactivated Hepatitis A Vaccine in Children With Chronic Liver Disease

Majda-Stanislawska, Ewa MD; Bednarek, Malgorzata MD; Kuydowicz, Jan MD

The Pediatric Infectious Disease Journal: June 2004 - Volume 23 - Issue 6 - p 571-574
doi: 10.1097/01.inf.0000130076.33497.6c
Brief Reports

One and 6 months after vaccination with hepatitis A virus vaccine (HAVRIX 720 Junior), immunologic responses (anti-hepatitis A virus ≥20 mIU/ml) in children with chronic hepatitis C infection seroprotection were 92% (23/25) and 75% (9/12) in children with chronic hepatitis B infection 87% (21/24) and 88% (15/17) and in healthy children 91% (20/22) at both times. A booster dose induced seroprotection in all children.

From the Department and Clinic of Infectious Diseases and Hepatology, Medical University of Lodz, Lodz, Poland

The vaccines and anti-HAV antibody tests used for the study were sponsored by GlaxoSmithKline Biologicals. None of the authors has any other potential conflict of interests related to the work.

Accepted for publication January 30, 2004.

Reprints not available.

© 2004 Lippincott Williams & Wilkins, Inc.