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INTUSSUSCEPTION AND ROTAVIRUS VACCINES: WHAT IS THE BACKGROUND RISK?

Sáez-Llorens, Xavier M.D.; Guevara, Javier Nieto M.D.

The Pediatric Infectious Disease Journal: April 2004 - Volume 23 - Issue 4 - p 363-365
Brief Reports

The first rotavirus vaccine was associated with a small, albeit statistically significant, risk of intussusception in immunized infants. Before results of new vaccine studies are available, we need to define the real background risk of intussusception in participating countries. A 5-year retrospective study conducted in Panama found an average rate of 1 case per 3300 infants younger than 1 year of age, with substantial yearly variations ranging from 1:2500 to 1:5000.

Pediatrics University of Panama Infectious Diseases Hospital del Niño Panama City, Panama

Reprints not available

Accepted for publication Dec. 5, 2003.

© 2004 Lippincott Williams & Wilkins, Inc.