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Pneumococcal endocarditis in infants and children

CHOI, MARGARET MD; MAILMAN, TIMOTHY LLOYD MD, FRCPC

The Pediatric Infectious Disease Journal: February 2004 - Volume 23 - Issue 2 - p 166-171
doi: 10.1097/01.inf.0000109290.91866.93
Review Article

We report a case of pediatric pneumococcal endocarditis (PPE) and review the English language literature on this disease. Thirty-two cases of PPE were identified since 1900. One-fourth of these were reported since 1990. Clinical features differed from adult cases, with mitral valve involvement being more frequent and Osler’s triad rarely present in children. Congenital heart disease was the only identifiable risk factor. Medical therapy alone resulted in a high mortality rate that was improved in the group of patients receiving combined medical and surgical interventions. PPE is a rare infection that has been reported more frequently in the era of increasing antibiotic resistance. Unlike typical “subacute” endocarditis caused by viridans streptococci, PPE is an aggressive disease with a high mortality rate. Early surgical intervention might improve survival.

From the Department of Pediatrics, University of British Columbia, British Columbia Children’s Hospital, Vancouver, British Columbia (MC); and the Department of Pediatrics, Dalhousie University, IWK Health Center, Halifax, Nova Scotia (TLM), Canada.

Accepted for publication Nov. 4, 2003.

Address for reprints: Dr. Tim Mailman, Department of Pediatrics, Dalhousie University, IWK Health Center, 5850 University Avenue, Halifax, Nova Scotia B3J 3G9, Canada. Fax 902-470-7046. E-mail Tim.Mailman@iwk.nshealth.ca.

© 2004 Lippincott Williams & Wilkins, Inc.