We present a fatal case of neonatal invasive group A streptococcal disease and review of the literature. Twenty-four cases were early onset disease and were associated with concurrent maternal infection, respiratory distress, pneumonia, toxic shock-like syndrome and serotype M1. Fifteen cases were late onset disease associated with soft tissue infections and meningitis. Maternal carriage was identified as an important factor in neonatal group A streptococcal disease.
From the Division of Pediatric Infectious Diseases (JB) and the Department of Pediatrics (IM, DB), Long Island College Hospital, Brooklyn, NY; and the Clinical Microbiology Laboratory and the Department of Pathology (JP), Beth Israel Medical Center, New York, NY.
Accepted for publication Oct. 30, 2003.
Address for reprints: Isao Miyairi, M.D., Department of Infectious Diseases, St. Jude Childrens Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105. E-mail Isao.Miyairi@stjude.org.