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Affordable diagnosis of human immunodeficiency virus infection in infants by p24 antigen detection

Sherman, Gayle G. M.Med. (Haem); Stevens, Gwynneth Ph.D.; Stevens, Wendy S. M.Med. (Haem)

The Pediatric Infectious Disease Journal: February 2004 - Volume 23 - Issue 2 - p 173-176
doi: 10.1097/01.inf.0000109332.83246.1a
Brief Reports

The expense of PCR testing limits diagnosis of HIV infection in infancy in low resource settings. The ultrasensitive p24 antigen assay has been proposed as an accurate substitute; however, its ability to detect different HIV viral subtypes remains to be determined. A sensitivity of 98.1% and specificity of 98.7% was obtained testing 203 samples from 24 HIV-infected and 66 uninfected infants born to HIV subtype C-infected women.

Department of Molecular Medicine and Haematology

National Health Laboratory Service

University of the Witwatersrand

Johannesburg, South Africa

Accepted for publication Oct. 19, 2003.

Reprints not available.

© 2004 Lippincott Williams & Wilkins, Inc.