Institutional members access full text with Ovid®

Share this article on:

Combination therapy with caspofungin and liposomal amphotericin B for invasive aspergillosis

ELANJIKAL, ZIJU MD; SÖRENSEN, JAN MD; SCHMIDT, HELGA MD; DUPUIS, WOLFGANG MD; TINTELNOT, KATHRIN MD; JAUTZKE, GÜNTER MD; KLINGEBIEL, THOMAS MD; LEHRNBECHER, THOMAS MD

The Pediatric Infectious Disease Journal: July 2003 - Volume 22 - Issue 7 - p 653-656
doi: 10.1097/01.inf.0000073060.20277.29
Instructive Case

Ina 24-month-old girl with acute lymphoblastic leukemia and invasive aspergillosis, only combination therapy with liposomal amphotericin B and caspofungin achieved a good response. Combination therapy could be a useful treatment option in children with invasive fungal disease, but before it can be routinely recommended, carefully controlled in vivo studies and well-designed randomized clinical trials are needed.

From the Departments of Pediatric Hematology and Oncology, Children′s Hospital III (ZE, JS, TK, TL) and Pediatric Radiology (HS), University of Frankfurt, Frankfurt; Children’s Hospital, Städtische Kliniken, Karlsruhe (WD); and Robert Koch-Institute (KT) and Hospital Sankt Gertrauden (GJ), Berlin, Germany.

Accepted for publication March 24, 2003.

Address for reprints: Thomas Lehrnbecher, M.D., Department of Pediatric Hematology and Oncology, Children′s Hospital III, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt. Fax 49-69-6301-6700; E-mail thomas_lehrnbecher@yahoo.com.

© 2003 Lippincott Williams & Wilkins, Inc.