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Successful treatment of foscarnet-resistant herpes simplex stomatitis with intravenous cidofovir in a child

Bryant, Penelope MRCPCH; Sasadeusz, Joe FRACP, PhD; Carapetis, Jonathan FRACP, PhD; Waters, Keith FRACP; Curtis, Nigel MRCPCH, PhD

The Pediatric Infectious Disease Journal: November 2001 - Volume 20 - Issue 11 - p 1083-1086
Instructive Case

A leukemic child developed recurrent herpes simplex virus lesions shortly after receiving a bone marrow transplant and while taking acyclovir. The isolate was resistant to acyclovir and foscarnet in vitro. The lesions responded to a course of cidofovir.

From the Departments of Microbiology and Infectious Diseases (PB, JC, NC), Paediatrics (JC, NC) and Haematology and Oncology (KW), University of Melbourne, Royal Children’s Hospital, and Victorian Infectious Diseases Service, Royal Melbourne Hospital (JS), Parkville Victoria, Australia.

Accepted for publication April 26, 2001.

Reprints not available.

© 2001 Lippincott Williams & Wilkins, Inc.