Objective. To describe the variability and appropriateness of antibiotic prescriptions in community-acquired acute respiratory infections (ARI) during childhood in Spain.
Methods. A descriptive, multicenter study of variability in clinical practice was conducted by evaluating a prospective series of pediatric patients attending the emergency rooms of 11 Spanish hospitals and diagnosed with community-acquired ARI. The appropriateness of the antibiotic prescriptions was assessed by comparing our clinical practice with consensus guidelines developed for this study.
Results. We collected data from 6,249 ARI emergencies studied on 30 separate days. Antibiotics were prescribed in 58.7% of the ARI (bronchiolitis, 11.5%; bronchitis, 40.2%; pharyngotonsillitis, 80.9%; nonspecified ARI, 34.8%; pneumonia, 92.4%; otitis, 93.4%; sinusitis, 92.6%). The most commonly used antibiotics were amoxicillin/clavulanate (33.2%), amoxicillin (30.2%), cefuroxime axetil (8.5%) and azithromycin (6%). According to the consensus guidelines developed for this study, therapy was considered to be appropriate in 63.1% of the ARI (first choice, 52.1%; alternative choice, 11.0%) and inappropriate in 36.9%. The percentages of inappropriate prescription according to ARI groups were: bronchiolitis, 11.5%; bronchitis, 31.5%; pharyngotonsillitis, 54.8%; nonspecified ARI, 34.7%; pneumonia, 13.9%; otitis, 25.6%; and sinusitis, 22.2%.
Conclusions. There is excessive use of antibiotics in acute respiratory infections that are presumably viral in origin. An important number of ARI of potentially bacterial origin are treated with antibiotics that are not sufficiently efficacious or that have a broader spectrum than necessary.
From Unidad de Investigación, Hospital Virgen de la Concha, Zamora (CO); Servicio de Medicina Interna, Hospital Medina del Campo (LI), and Departamento de Microbiología, Hospital Universitario (JME), Valladolid; Servicio de Pediatría, Hospital de Cabueñes, Gijón (GS); Servicio de Farmacología Clínica, Hospital Vall d’Hebron, Barcelona (AV); and Plan Nacional del Sida, Ministerio de Sanidad y Consumo, Madrid (LG), Spain.
Accepted for publication April 3, 2001.
Address for reprints: Dr. Carlos Ochoa Sangrador, Unidad de Investigación, Hospital Virgen de la Concha, Avenida Requejo 35, 49029 Zamora, Spain. Fax 34 980-512838; E-mail email@example.com.