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Pediatric Physical Therapy:
doi: 10.1097/PEP.0b013e31818b7ccd
Research Report

Systematic Review of Progressive Strength Training in Children and Adolescents with Cerebral Palsy Who Are Ambulatory

Mockford, Margaret MSc, MCSP; Caulton, Janette M. MSc, MCSP

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Author Information

Physiotherapy Department (M.M.), Blackfriars School, North Staffordshire NHS Primary Care Trust, Newcastle-under-Lyme, Strafforshire, United Kingdom; and School of Health and Rehabilitation (J.M.C.), Faculty of Health, Keele University, Keele, Staffordshire, United Kingdom

Address correspondence to: Margaret Mockford, Physiotherapy Department, Blackfriars School, Priory Road, Newcastle-under-Lyme ST5 2TF, United Kingdom. E-mail: margaret.mockford@ukonline.co.uk

This article originated from the dissertation completed in partial fulfilment of the Master of Science degree at Keele University, by Margaret Mockford.

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Abstract

Purpose: To capture and analyze the evidence concerning the effects of progressive strength training on function and gait in children and adolescents with cerebral palsy (CP) who are ambulatory.

Method: A language-inclusive search was conducted for controlled or noncontrolled studies of strength training for subjects with CP who were ambulatory and aged 4 to 20 years, using objective outcome measures. Quality was assessed with the Maastricht-Amsterdam List. Data were extracted and analyzed.

Results: The 13 included articles favored treatment without significant adverse effects. Function and gait improved more following isotonic rather than isokinetic training, and in younger rather than older subjects.

Conclusions: Function and gait improvements were greater in preadolescents.

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INTRODUCTION

Cerebral palsy (CP) is defined as “… non-progressive, but often changing, motor impairment syndromes secondary to lesions or anomalies of the brain arising in the early stages of its development.”1(p9) CP occurs in approximately 2 of every 1000 live births in Europe2 and 2.4 of every 1000 live births in the United States.3 Motor abilities develop during childhood but eventually a plateau is reached.4 Children risk losing some functional abilities during adolescence because of ongoing secondary impairments such as soft tissue shortening, weakness, and bony deformity.5 In particular, teenagers who are ambulatory may lose distance, speed, or quality of walking.6 Recent government legislation in the United Kingdom focuses attention on preparing children for adult life7; as participation in society is correlated with independent mobility,8 it is important to examine gait deterioration.

Strength-training interventions involve effort against progressive resistance. Historically, clinicians attempted to address weakness in subjects with CP by applying the principles of DeLorme in strength-training programs.9 With the advent of neurodevelopmental therapy, however, clinical practice largely followed the teaching that weakness is not a major problem in CP.10 Treatment was focused on inhibiting spasticity,11 and excessive effort was avoided as it was believed to increase spasticity and impair motor control.12 More recently, experts have questioned these premises, in identifying that both spasticity and weakness are part of the upper motor neurone syndrome13 and may coexist in the same muscle.14 There is some evidence that function is related to both strength and spasticity.15 Children with CP are significantly weaker than their peers16 and weakness may be evident in all muscles around a joint.17

Two previous reviews of strength training in CP found all included studies indicated the intervention increased muscle strength.18,19 A systematic review20 of literature published up to March 2000 used a thorough search strategy, but was limited to English language papers. The review included upper and lower limb studies of subjects with CP both ambulatory and nonambulatory; most were children and teenagers, but 1 study included adults up to 47 years. The broad inclusion criteria increased clinical heterogeneity and generalizability but limited internal validity. All 23 included studies favored strength training but negative studies may have been missed by exclusion of non-English papers.21 The authors concluded strength training improves strength but further research is needed to ascertain activity and participation outcomes, to establish optimum dosages, and to investigate longer-term effects.

The current review included non-English papers, and limited the clinical heterogeneity through a more focused research question. This review aimed to ascertain the current worldwide evidence about progressive strength training for children and adolescents with cerebral palsy who are ambulatory, with particular regard to function and gait outcomes.

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METHOD

Search Strategy

A comprehensive language-inclusive search strategy was devised. This was validated by an experienced medical librarian. The search strategy was applied to 8 databases (MEDLINE, AMED, CINAHL, Cochrane Library, EMBASE, PEDro, PsycInfo, and SPORTDiscus) without limitations on publication dates up to March 2007. The keywords were as follows: population cerebral palsy; intervention strength training, strengthening, strength exercise, weight training, weight lifting, resisted exercise, resistance exercise, resisted training, resistance training. A supplementary search attempted to find literature missed by electronic searching. Expert researchers in the field were contacted, in an effort to locate any unpublished studies. Details of the search strategy are available from the authors.

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Inclusion/Exclusion Criteria

The inclusion criteria for this review were (1) any experimental or quasi-experimental study, or single-group preexperimental studies; involving (2) subjects aged 4 to 20 years with cerebral palsy, ambulatory with/without aids and able to follow simple instructions; (3) any intervention aimed at strengthening one or more lower limb muscles and with some means of exercise progression; (4) any objective measure of walking ability, function, and/or strength. These criteria were narrower than those of the previous review20 as upper limb studies, adults, and subjects who were nonambulatory were excluded.

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Study Selection

Initially, the inclusion criteria were applied liberally to the citations, the abstract of each likely citation was read and the full manuscript obtained of each of those possibly meeting the inclusion criteria. If the abstract was unavailable, the full manuscript was obtained. Foreign language papers were translated. The inclusion criteria were stringently applied to each full manuscript by 2 independent reviewers to yield a final set of papers. If a full manuscript or translation was unobtainable, that paper had to be excluded.

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Quality Assessment and Levels of Evidence

The Maastricht-Amsterdam List (MAL) quality assessment tool was chosen for this review as it scores both controlled and noncontrolled studies. Two independent reviewers applied the full 19-item MAL to controlled studies and the modified 14-item MAL to noncontrolled studies.22 Assessment reliability was increased by use of Operationalisation Guidelines (Appendix A) devised from the guidelines for the tools from which the MAL had been derived.23–26 These Guidelines were refined through a 3-stage pilot study by the 2 reviewers. This resulted in the level of agreement, as measured by the unweighted kappa statistic, between the 2 reviewers rising from 0.6162 (standard error 0.0742; 95% confidence interval 0.4708–0.7616) to 0.7194 (standard error 0.1095; 95% confidence interval 0.5047–0.9341). This indicates the strength of agreement increased from “moderate/substantial” to well within the “substantial” range.27 The frequent disagreements over items k and n were eradicated and the items on which they disagreed became more random.

The total score and the subscores for descriptive, internal validity, and statistical criteria were tabulated and compared with the MAL bench-mark scores (Table 1). Sackett’s Levels of Evidence and Grades of Recommendation guidelines were also applied to the included studies28 (Appendix B).

Table 1
Table 1
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Data Extraction and Analysis

The MAL quality scores were converted to percentages to enable comparisons. Data were extracted from each included study. Meta-analysis was beyond the scope of this review and was likely to be inappropriate because of heterogeneity of studies; descriptive statistics, however, were used to summarize findings. Within-group effect size statistics were calculated where possible and then averaged for each principal outcome type. According to Cohen’s guidelines, an effect size of ≤0.2 is small, 0.5 is medium, and 0.8 is large.27 Confidence intervals for within-group estimates were not calculated, as these are beyond the scope of this review. Subgroup analyses were carried out where possible. The effects of detraining were examined in studies with a postintervention follow-up period.

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RESULTS

Eighty-seven studies were identified by abstracts. Thirty-four full articles were reviewed, including 4 non-English studies. Finally 13 studies29–41 were included in this review, including 1 non-English study.36 No study was excluded because of translation difficulties, but 3 of the 4 unobtainable studies were non-English.

The Maastricht-Amsterdam List quality scores for the 13 included studies are shown in Table 2. Two high-quality RCTs gave level 1b evidence33,37 and 3 low quality RCTs gave level 2b evidence.35,36,41 The 8 noncontrolled studies gave level 4 evidence of which 6 met the criteria for “sufficient quality”28–32,39 and 2 were of lower quality.34,40 The 5 RCTs yield a grade B recommendation for treatment28 (Appendix B).

Table 2
Table 2
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Internal validity was compromised by lack of blinding. Subjects and therapists cannot be blinded to strength training but only 6 of 13 studies30,32,33,37,39,41 blinded the assessors (Table 2). Avoidance of cointerventions was inadequate in 8 of 13 studies32,34–36,38–41 and adequate compliance was described in only 7 of 13 studies.29–31,33,37–39 The method of randomization was not clear in 3 of 5 RCTs.35–37 However, most studies either had no drop-outs or described these subjects adequately. The descriptive and statistical criteria of the MAL tool were mostly fulfilled with the exception of a long-term outcome which was carried out in only 4 studies.

A total of 138 subjects participated in strength training, most were described as having spastic-type CP, mainly of hemiplegic or diplegic distribution. Most studies provided the intervention 3 times per week (range 1–5) over 6 weeks (range 4–12). Ten studies involved open and/or closed chain isotonic exercises and 235,38 gave isokinetic exercises. Resistance was applied using free weights, body weight, weighted backpacks, elastic bands, weight machines, or an isokinetic machine. Most studies included warm-up and cool-down activities, some included stretches or balance exercises, but all described strength training as the major intervention. The setting varied but all except one34 had adult supervision.

Study data are shown in Tables 3 and 4. Data for function and gait outcomes were incomplete as some studies did not provide sufficient information for effect sizes to be calculated. Data could not be pooled due to heterogeneity between studies and missing data. The 2 reports of the study by Damiano et al30,31 were considered 1 study to avoid double-counting.

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Strength

Seven studies29–33,37,39,40 measured isometric strength and overall this was increased following isotonic exercising. The 2 studies using isokinetic exercises35,38 measured results isokinetically and found a significant improvement. One study providing isotonic exercises40 found both isokinetic and isometric strength was improved. Measures of effect all favored treatment, with 7 of these regarded as large effects27 (Table 5).

Table 5
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Two studies30–32 found strengthening the quadriceps moved the quadriceps-hamstrings ratio further from the normal, but 1 study39 strengthened quadriceps and hamstrings and found the ratio moved nearer to normal. One study40 found that isometric quadriceps strength showed greatest improvements at longer muscle lengths but another30,31 found greatest gains at shorter lengths.

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Function

To measure functional changes, 7 studies used the Gross Motor Function Measure. Six32,33,35–37,39 of these studies found some improvement at least in dimension E and one38 did not report scores but approximately half the sample improved. One further study29 found significant improvement in 3 weight-bearing functional tests; where effect size could be calculated all favored treatment, but 3 of 632,33,35 studies showed small effects27 (Table 5).

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Gait

Most studies assessed gait. Four studies30–32,35,41 used 3D gait analysis (3DGA) and found improvements in some gait parameters, although this was not always statistically significant. One study34 using visual gait analysis found similar results. Timed walking tests29,33,34,36,37,39 found mixed results and timed stair-climbing33 showed nonsignificant improvements. All studies favored treatment, with small-to-moderate effects27 (Table 5).

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Subgroup Results

Preadolescent children showed large effects for strength and moderate effects for gait; adolescents also showed large effects for strength, but smaller effects for gait (Table 5). Subgroup results concerning clinical severity were mostly unidentifiable because of lack of individual or subgroup data in reports. Children with diplegia showed greater strength gains than those with hemiplegia in 2 studies,32,38 but no difference in 1 study.41 Two studies34,36 gave no diagnostic subgroup results. Subjects with diplegia comprised the entire sample in 7 studies.29,30,31,33,35,37,39,40

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Detraining

Reassessment after a period of detraining found isometric strength was maintained or slightly increased29,33,39 but isokinetic strength deteriorated38 (Fig. 1A). Function test results29,33 were maintained or slightly increased (Fig. 1B). Gait parameters showed a reduction of gains seen post-training, although these did not return to baseline levels (Fig. 1C). The length of detraining for these studies ranged from 4 to 12 weeks.

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Other Results

No study found an increase in muscle tone; 2 found a significant decrease, as measured by an isokinetic dynamometer35 or by resistance to passive stretch on a myometer.39 A few mild adverse events were recorded which were mostly muscle or joint soreness. The most serious adverse event was development of knee hyperextension in 5 subjects30,31 who had previously had hamstring-lengthening surgery.

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DISCUSSION

Quality of Included Studies

Quality scores indicate sufficient internal validity in more noncontrolled studies (5 of 7) than RCTs (2 of 5). The effects in the noncontrolled studies were mostly larger than in the RCTs, but in the same direction. It is acknowledged that a systematic review including more high quality RCTs would produce more robust evidence, but given the paucity of RCTs in this clinical area the included noncontrolled studies are valuable.42 Their findings add strength to the body of evidence.

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Effect of Strength on Function and Gait

An intervention should have an effect on the level of disability measured by activity and participation outcomes.43 Knee muscle strength is moderately and significantly correlated with GMFM scores and standing balance in children and young people with CP.15,44–46 Many neuromuscular and musculoskeletal deficits, however, interfere with motor function in CP and successful intervention depends on identifying which is the most limiting impairment.47 Impairments other than strength may have been significant as several included studies33,39,41 indicated that some subjects had previously had interventions for spasticity, soft tissue contractures, and bony deformities. Selective motor control is infrequently measured but was found to be significantly limiting in younger children.48 Teenagers may have more advanced soft tissue contractures and joint deformities that could limit improvements in gait and function, independent of muscle strength. The GMFM may have a ceiling effect in older subjects, thereby masking true functional gains.49 As gait deterioration is common in teenagers with CP it may be that nonsignificant gains38 were clinically meaningful, in that subjects did not deteriorate. Here the intervention is fighting the natural course of the condition, whereas preadolescent children are likely to acquire motor skills4 and the strength training simply enhances this.

There may have been a ceiling effect in the more able subjects with hemiplegia.49 Strength training in adults following stroke showed variable carryover to function50 which was possibly partly due to compensation using the uninvolved side. If subjects with hemiplegic CP have developed compensatory ways of functioning, increased strength may not alter or normalize these. The involved side remains weaker than the uninvolved side, especially during short strength-training interventions. Subjects with diplegia are less likely to compensate in this way so weakness may be more clearly reflected in functional scores. The effect of strength on athletic performance in children who are developing typically is inconclusive.51 If the movement quality of subjects with CP is altered following training, the GMFM does not identify this.52

It has been suggested that strength-training protocols should match functional tasks to facilitate learning53 but this was performed in only 3 studies.29,36,37 Motor learning is also influenced by an individual’s attitude, environment, and capacity to solve motor problems and harness abilities in different contexts.54 Carryover of strength gains to functional activities may not be immediate and 3 studies29,33,39 showed higher function scores at detraining follow-up. Strength gains may have allowed these children to practice improved functional activities without further training. Croce and DePaepe55 argue that children must learn an action to the point of automatic execution before it is incorporated into other activities, which could be related to the intensity and length of studies.

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Crouch Gait

Three studies30,31,35,41 found significantly improved knee extension during walking. Crouch gait with excessive hip and knee flexion in stance is common in subjects with CP and deteriorates without intervention.56 During normal gait, the hip and knee extensors work in a shortened position. Isometric testing identified muscles of subjects with CP appear weaker when working at shorter lengths30,31,40,57; they may collapse into crouch because they are unable to exert sufficient extensor force in the shortened position. It is unclear whether strength training can alter this length-tension relationship. One study of isotonic open-chain strength training30,31 identified greater strength gains at the shortest quadriceps length, possibly because the free leg achieves greater knee extension during training without opposition by body weight. The quadriceps work therefore in their weaker shortened range where a training effect may then occur. One study30,31 found knee extension at heel strike significantly improved: the similarity of this gait action to the training action may account for this. A muscle, however, rarely functions in isolation; the incomplete carryover of strength to function and gait following open-chain exercising may be because of differences in the intensity, frequency, and range of motion used in the weight-bearing studies.58 Additionally, as isolated work at one joint is often difficult for children with spasticity, whole-limb activities may be more achievable.48,59

Training should be specific regarding muscle length, peak force, activation patterns, timing, amplitude, and contraction type.58 The 2 isokinetic studies35,38 found little carryover to function and gait parameters; this indicates strength gained isokinetically may be less functionally useful, as isokinetic movement does not occur in everyday function. Closed-chain isotonic exercises however are similar to the gait parameters the intervention is designed to improve. If strength gains are initially due to improved neural activation, then the training effect from closed-chain exercise is more specific to gait and weight-bearing functions. Additionally Bobath12 suggested weakness may partly be attributable to tactile or proprioceptive sensory deficits and is counteracted by massive sensory stimulation. Electrical stimulation increases strength perhaps partly because it alters sensory inputs that affect the excitability of interneurones and motor neurones.17 Closed-chain strength training may enhance sensory inputs by stimulating the proprioceptors in weight-bearing tissues which may improve motor recruitment. Sensory input may also improve body image deficiency, thereby facilitating better voluntary control.60

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Gait Velocity

The crouched position is inefficient, which reduces gait velocity.61 Whereas, there is good correlation between strength and velocity in subjects who are developing typically, improved strength in subjects with CP can only increase velocity in the absence of other more limiting impairments.62 When subjects with CP walk faster, they tend to increase cadence32,39 rather than stride length and show increased pelvic excursion, but not increased knee and hip excursion.63 The child relies on proximal trunk muscles to propel the legs forwards, so improved leg strength may have limited effects on velocity.64 Significantly increased stride length29,30,31,34,35,39 may be indicative of reduced crouch or greater stability of the stance leg.46

Most studies using the timed stair climb and timed 10 m walk,29,33,36,39 or measuring maximum velocity walking as part of 3DGA,30–32,35 found some improvement. These tests assess maximum-effort performance and may reflect the maximum-effort training protocol used. One study37 found no significant change in maximum gait velocity; this study trained younger subjects by resisted sit-to-stand exercise, which may not have sufficiently influenced activity of the lower limb extensors in an upright walking position.

The 2 or 3-minute walk test at a self-selected pace is more indicative of walking ability for everyday function. Four studies32,34–36 found significant improvement in velocity, but another 4 found no significant change.29–31,38,41 Subjects with CP expend 2 to 3 times the normal amount of energy in walking, which causes excessive fatigue; they tend to select a velocity and cadence that minimizes this fatigue.65 Fatigue is identified as significant in many adults with CP66 and may be the most limiting factor in the walking test, indicating strength training may not adequately address this factor.

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Gait Abnormality

Thelen et al67 argue abnormal coupling of hip and knee moments indicates CP gait is inherently altered and is not simply a weaker form of normal gait. Steinwender et al68 suggest that as the muscle activation pattern is abnormal, it may not be improved by strength training and it may even be reinforced. Farmer6 suggests gait in subjects with CP is immature rather than abnormal, as the muscle firing sequences are similar to those of infants developing typically, but not similar to those of children who are maturing. Weakness and contractures induce compensatory strategies, eventually producing a gait that is both altered and slower.64,69 The wide range of gait results at self-selected and fast velocities indicate subjects showed various abnormalities and compensations, so general conclusions cannot be drawn.

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Gait Deterioration

The maintenance of walking into adulthood is a concern often voiced by parents, this may be influenced by many factors.66 Stride length reduces with age and double support increases.6 Joint deterioration is a significant factor in loss of walking, and the increased patellofemoral force induced by the crouched posture can cause chronic pain.5,56 The effort required for walking increases with increasing height and weight, which causes premature fatigue.70,71 Furukawa et al72 found reduced coordination and stability because of deformity, spasticity and weakness, which explained the deterioration in walking ability of 18 children with CP aged 9 to 14 years. General fitness was not a significant factor. Loss of confidence also affects young people’s walking ability.70 Strength training could positively influence many of these factors by increasing stride length29–31,34,35 and joint excursion,30,31,35 and by decreasing double support32 and crouch.30,31,35,41 Psychological benefits were not examined by this review, but some evidence exists for increased self-confidence and self- esteem which may encourage young people to realize greater physical potential.73 Nevertheless, literature concerning gait in young people with CP lacks specific evidence about who is most susceptible to deterioration and why.74 Future research should examine factors predisposing to gait deterioration and the use of strength training in conjunction with other interventions to maximize retention of functional and gait abilities.

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Limitations of this Review

Unpublished or nonindexed foreign-language studies may have been missed by the search strategy. These could be more likely to have negative results which would affect the review’s findings.21,75 Study comparisons were limited as not all measured the same variables; some data were insufficient and missing data were not requested from the authors. Some eligible subjects in other studies spanning the age-limit of 20 years were excluded, as authors could not be contacted for individual data within the parameters of this review. The MAL tool has face and content validity and interrater reliability, but no other established psychometric properties.76 This is in common with many quality assessment tools used in rehabilitation research. Although it was developed from 2 tools with well-established validity and reliability, the Jadad Scale24 and the Delphi List25, their psychometric credentials cannot be directly transferred to the new tool.76 The use of Operational Guidelines for this systematic review resulted in substantial interrater reliability of the MAL.27 Within-group effect size calculations enabled comparisons between all studies, but between-group calculations were not performed for the 5 RCTs. Incomplete age and diagnosis subgroup data limited inferences.

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CONCLUSIONS

Isotonic strength training was associated with moderate-to- large strength and function gains which were maintained after detraining, and small-to-moderate gait improvements that partially deteriorated during detraining. Two studies found isokinetic training enhanced strength with less significant effects on gait and function and some loss after detraining. Strength training may enhance motor development in younger children; it may counteract deterioration in youth, where statistically nonsignificant results may be clinically meaningful. Strength training may ameliorate some aspects of gait in children and youth with CP in the absence of more limiting factors. Secondary impairments, particularly in postadolescent youth, may limit carryover of strength gains to gait and function. Subjects experienced no increased spasticity or other serious side-effects.

The 3 previous reviews of English publications18–20 concluded strength training in CP improves muscle strength but were inconclusive regarding gait and function. They included more heterogeneous populations than this review, but presented no subgroup results. Detraining effects were not discussed. This review is therefore in accordance with previous findings, following a wider language-inclusive search and analysis of more recent literature. This review concerns a narrower population, adds findings for subgroups and detraining effects, and contributes to knowledge regarding gait and function outcomes.

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REFERENCES

Bax M, Brown J. 2004 The spectrum of disorders known a cerebral palsy. In: Scrutton D, Damiano D, Mayston M, eds. Management of the Motor Disorders of Children with Cerebral Palsy. 2nd ed. London: Mac Keith Press; 2004:9–21.

Johnson A, corresponding author for Surveillance of Cerebral Palsy in Europe. Prevalence and characteristics of children with cerebral palsy in Europe. Dev Med Child Neurol. 2002;44:633– 640.

Hirtz D, Thurman D, Gwinn-Hardy K, et al. How common are the common neurologic disorders? Neurology. 2007;68:326–337.

Rosenbaum P, Walter S, Hanna S, et al. Prognosis for gross motor function in cerebral palsy. JAMA. 2002;288:1357–1363.

Gajdosik C, Cicirello N. Secondary conditions of the musculoskeletal system in adolescents and adults with cerebral palsy. Phys Occup Ther Pediatr. 2001;21:49–68.

Farmer S. Key factors in the development of lower limb coordination: implications for the acquisition of walking in children with cerebral palsy. Disabil Rehabil. 2003;25:807–816.

Children Act 2004. Available at: www.everychildmatters.gov.uk/outcomes. Accessed December 6, 2006.

Lepage C, Noreau L, Bernard P. Association between characteristics of locomotion and accomplishment of life habits in children with cerebral palsy. Phys Ther. 1998;78:458–469.

Healy A. Two methods of weight-training for children with spastic type of cerebral palsy. Res Q. 1958;29:389–395.

Bobath B. Motor development, its effect on general development, and application to the treatment of cerebral palsy. Physiotheraphy. 1971;57:526–532.

Levitt S. Treatment of Cerebral Palsy and Motor Delay. Oxford: Blackwell Scientific Publications; 1977.

Bobath B. Adult Hemiplegia: Evaluation and Treatment. 3rd edition. Oxford: Butterworth-Heinemann; 1990.

Pandyan A, Gregoric M, Barnes M, et al. Spasticity: clinical perceptions, neurological realities and meaningful measurement. Disabil Rehabil. 2005;27:2–6.

Mayston M. Strength-training for children with cerebral palsy. Assoc Paediatr Chartered Physiother. 2003;107:14–18.

Damiano D, Quinlivan J, Owen B, et al. Spasticity versus strength in cerebral palsy: relationships among involuntary resistance, voluntary torque, and motor function. Eur J Neurol. 2001;8(suppl 5):40–49.

Wiley M, Damiano D. Lower-extremity strength profiles in spastic cerebral palsy. Dev Med Child Neurol. 1998;40:100–107.

Rose J, McGill K. The motor unit in cerebral palsy. Dev Med Child Neurol. 1998;40:270–277.

Darrah J, Fan J, Chen L, et al. Review of the effects of progressive resisted muscle strengthening in children with cerebral palsy: a clinical consensus exercise. Paediatr Phys Ther. 1997;9:12–17.

Haney N. Muscle strengthening in children with cerebral palsy. Phys Occup Ther Pediatr. 1998;18:149–157.

Dodd K, Taylor N, Damiano D. A systematic review of the effectiveness of strength-training programmes for people with cerebral palsy. Arch Phys Med Rehabil. 2002;83:1157–1164.

Egger M, Smith G. Bias in location and selection of studies. BMJ. 1998;316:61–66.

Steultjens E, Dekker J, van de Nes J, et al. Occupational therapy for children with cerebral palsy: a systematic review. Clin Rehabil. 2004;18:1–14.

Van Tulder M, Assendelft W, Koes B, et al; and the editorial board of the Cochrane Collaboration Back Review Group. Method guidelines for systematic review in the Cochrane collaboration back review group for spinal disorders. Spine. 1997;22:2323–2330.

Jadad A, Moore A, Carroll D, et al. Assessing the quality of reports of randomised clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1–12.

Verhagen A, de Vet H, de Bie R, et al. The Delphi List: a criteria list for quality assessment of randomised clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol. 1998;51:1235–1241.

Van Tulder M, Furlan A, Bombardier C, et al; and the Editorial Board of the Cochrane Collaboration Back Review Group. Updated methods guidelines for systematic reviews in the Cochrane Collaboration Back Review Group. Spine. 2003;28:1290–1299.

Sim J, Wright C. Research in Health Care: Concepts, Designs and Methods. Cheltenham: Nelson Thornes; 2000.

Centre for Evidence-Based Medicine. Section on EBM tools, levels of evidence. Available at: www.cebm.net. Accessed April 24, 2006.

Blundell S, Shepherd R, Dean C, Adams R. Functional strength training in cerebral palsy: a pilot study of a group circuit training class for children aged 4–8 years. Clin Rehabil. 2003;17:48–57.

Damiano D, Vaughan C, Abel M. Muscle response to heavy resistance exercise in children with spastic cerebral palsy. Dev Med Child Neurol. 1995;37:731–739.

Damiano D, Vaughan C, Abel M. Effects of quadriceps femoris muscle strengthening on crouch gait in children with spastic diplegia. Phys Ther. 1995;75:658–671.

Damiano D, Abel M. Functional outcomes of strength training in spastic cerebral palsy. Arch Phys Med Rehabil. 1998;79:119–125.

Dodd K, Taylor N, Graham H. A randomized clinical trial of strength training in young people with cerebral palsy. Dev Med Child Neurol. 2003;45:652–657.

Eagleton M, Iams A, McDowell J, et al. The effects of strength training on gait in adolescents with cerebral palsy. Pediatr Phys Ther. 2004;16:22–30.

Engsberg J, Ross S, Collins D. Increasing ankle strength to improve gait and function in children with cerebral palsy: a pilot study. Pediatr Phys Ther. 2006;18:266–275.

Jiang Q, Liu P, Wang C. The effect of functional strength training in spastic cerebral palsy. Chin J Rehabil Med. 2006;21:896–898, 943.

Liao H, Liu Y, Liu W, et al. Effectiveness of loaded sit-to-stand resistance exercise for children with mild spastic diplegia: a randomised clinical trial. Arch Phys Med Rehabil. 2007;88:25–31.

MacPhail H, Kramer JF. Effect of isokinetic strength-training on functional ability and walking efficiency in adolescents with cerebral palsy. Dev Med Child Neurol. 1995;37:763–775.

Morton J, Brownlee M, McFadyen A. The effects of progressive resistance training for children with cerebral palsy. Clin Rehabil. 2005;19:283–289.

Tweedy S. Evaluation of strength and flexibility training for adolescent athletes with cerebral palsy. Aust Sports Commission. 1997:1–50.

Unger M, Faure M, Frieg A. Strength-training in adolescent learners with cerebral palsy: a randomised controlled trial. Clin Rehabil. 2006;20:469–477.

Barton S. Which clinical studies provide the best evidence? BMJ. 2000;321:255–256.

Kinsman S. Predicting gross motor function in cerebral palsy. JAMA. 2002;288:1399–1400.

Kramer J, MacPhail A. Relationships among measures of walking efficiency, gross motor ability, and isokinetic strength in adolescents with cerebral palsy. Pediatr Phys Ther. 1994;6:3–8.

Damiano D, Martellotta T, Sullivan D, et al. Muscle force production and functional performance in spastic cerebral palsy: relationship of cocontraction. Arch Phys Med Rehabil. 2000;81:895–900.

Lowes L, Westcott S, Palisano R, et al. Muscle force and range of motion as predictors of standing balance in children with cerebral palsy. Phys Occup Ther Pediatr. 2004;24:57–77.

Shumway-Cook A, Woollacott M. Motor Control: Theory and Practical Applications. 2nd edition. Baltimore: Lippincott Williams and Wilkins; 2004.

Ostensjo S, Brogen Carlberg E, et al. Motor impairments in young children with cerebral palsy: relationship to gross motor function and everyday activities. Dev Med Child Neurol. 2004;46:580– 589.

Boyd R, Graham H. Objective measurement of clinical findings in the use of botulinum toxin type A for the management of children with cerebral palsy. Eur J Neurol. 1999;6(suppl 4):S23–S35.

Morris S, Dodd K, Morris M. Outcomes of progressive resistance strength training following stroke: a systematic review. Clin Rehabil. 2004;18:27–39.

Bernhardt D, Gornez J, Johnson M, et al. Strength-training by children and adolescents. Pediatrics. 2001;107:1470–1472.

Ketelaar M, Vermeer A, Helders P. Functional motor abilities of children with cerebral palsy: a systematic literature review of assessment measures. Clin Rehabil. 1998;12:369–380.

Eng J. Strength training in individuals with stroke. Physiother Can. 2004;56:189–201.

Berendsen B, van Meeteren N, Helders P. Towards assessment of ‘motor intelligence’: a kick-off for debate. Adv Physiother. 2002;4:99–107.

Croce R, DePaepe J. A critique of therapeutic intervention programming with reference to an alternative approach based on motor learning theory. Phys Occup Ther Pediatr. 1989;9:5–33.

Arnold A, Anderson F, Pandy M, et al. Muscular contributions to hip and knee extension during the single limb stance phase of normal gait: a framework for investigating the causes of crouch gait. J Biomech. 2005;38:2181–2189.

Buckon C, Thomas S, Harris G, et al. Objective measurement of muscle strength in children with cerebral plays after selective dorsal rhizotomy. Arch Phys Med Rehabil. 2002;83:454–460.

Carr J, Shepherd R. Neurological Rehabilitation: Optimising Motor Performance. Oxford: Butterworth Heinemann; 1998.

Welmer A, Holmqvist L, Sommerfeld D. Hemiplegic limb synergies in stroke patients. Am J Phys Med Rehabil. 2006;85:112–119.

Galea M. Neural plasticity and learning: the potential for change. In: Scrutton D, Damiano D, Mayston M, eds. Management of the Motor Disorders of Children with Cerebral Palsy. 2nd ed. London: Mackeith Press; 2004:67–84

Yaggie J, Armstrong W. Spastic diplegic cerebral palsy: a brief introduction to its characteristics, assessment and treatment options. Clin Kinesiol. 2001;55:75–80.

Buchner D, Larsen E, Wagner E, et al. Evidence for a non-linear relationship between leg strength and gait speed. Age Ageing. 1996;25:386–391.

Abel M, Damiano D. Strategies for increasing walking speed in diplegic cerebral palsy. J Pediatr Orthop. 1996;16:753–758.

Nadeau S, Gravel D, Olney S. Determinants, limiting factors, and compensatory strategies in gait. Crit Rev Phys Rehabil Med. 2001;13:1–25.

Bennett B, Abel M, Wolovick A, et al. Centre of mass movement and energy transfer during walking in children with cerebral palsy. Arch Phys Med Rehabil. 2005;86:2189–2194.

Edwards S. Cerebral palsy in adult life. In: Scrutton D, Damiano D, Mayston M, eds. Management of the Motor Disorders of Children with Cerebral Palsy. 2nd ed. London: Mackeith Press; 2004:170–182.

Thelen D, Riewald S, Asakawa D, et al. Abnormal coupling of knee and hip moments during maximal exertions in persons with cerebral palsy. Muscle Nerve. 2003;27:486–493.

Steinwender G, Saraph V, Zwick E, et al. Hip locomotion mechanisms in cerebral palsy crouch gait [abstract]. Gait Posture. 2001;13:78–85.

Nadeau S, Gravel, Arsenault A, et al. Plantarflexor weakness as a limiting factor of gait speed in stroke subjects and the compensating role of the hip flexors. Clin Biomech. 1999;14:125–135.

Bottos M, Gericke C. Ambulatory capacity in cerebral palsy: prognostic criteria and consequences for intervention. Dev Med Child Neurol. 2003;45:786–779.

Jahnsen R, Villiers L, Stanghelle J, et al. Fatigue in adults with cerebral palsy in Norway compared with the general population. Dev Med Child Neurol. 2003;45:296–303.

Furukawa A, Nii E, Iwatsuki H, et al. Factors of influence on the walking ability of children with spastic cerebral palsy. J Phys Ther Sci. 1998;10:1–5.

McBurney H, Taylor N, Dodd K, et al. A qualitative analysis of the benefits of strength-training for young people with cerebral palsy. Dev Med Child Neurol. 2003;45:658–663.

Wu Y, Day S, Strauss D, et al. Prognosis for ambulation in cerebral palsy: a population-based study. Paediatrics. 2004;114:1264–1271.

Roberts I, Schierhout G. The private life of systematic reviews. BMJ. 1997;315:686–687.

Olivo S, Macedo L, Gadotti I, et al. Scales to assess the quality of randomised controlled trials: a systematic review. Phys Therap. 2008;88:156–175.

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Appendix A: The Maastricht-Amsterdam List and the Operationalization Guidelines

This quality assessment tool was recommended by van Tulder et al23 and incorporates the criteria proposed by Jadad et al24 and Verhagen et al.25 The recommended list was updated by van Tulder et al.26 These articles are therefore used to define the operationalization of the tool.

Each criterion is scored yes/no/unclear; one point is awarded for “yes,” otherwise no points are awarded. The tool gives a maximum of 19 points for controlled studies and 14 points for other designs.

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Patient Selection

a. Were the eligibility criteria specified? (Descriptive criterion) Statement of inclusion/exclusion criteria such that it is clear from what section of the overall cerebral palsy population the sample was drawn, and therefore to whom the study conclusions may be applied.

b1. Treatment allocation: was a method of randomization performed? (Internal validity criterion) “A method to generate the sequence of randomization will be regarded as appropriate if it allowed each study participant to have the same chance of receiving each intervention and the investigators could not predict which treatment was next. Methods of allocation using date of birth, date of admission, hospital numbers, or alternation should be not regarded as appropriate.”24 “Examples of adequate methods are computer generated random number table and use of sealed opaque envelopes.”26 The randomization method should be stated, not assumed.

b2. Treatment allocation: was the treatment allocation concealed? (Internal validity criterion) “Assignment generated by an independent person not responsible for determining the eligibility of the patients. This person has no information about the persons included in the trial and has no influence on the assignment sequence or on the decision about eligibility of the patient.”26 This should be stated, not assumed.

c. Were the groups similar at baseline regarding the most important prognostic indicators? (Descriptive criterion) ‘To receive a “yes,” groups have to be similar at baseline regarding demographic factors, duration and severity of complaints … and value of main outcome measure(s)’.26 There should be no statistically significant differences between the groups at baseline. Important prognostic indicators for this review would include age and severity of cerebral palsy.

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Interventions

d. Were the index and control interventions explicitly described? (Descriptive criterion) The intervention(s) should be described such that the reader could repeat the study, assuming a reasonable level of knowledge as a pediatric physiotherapist.

e. Was the careprovider blinded for the intervention? (Internal validity criterion) ‘The reviewer determines if enough information about the blinding is given in order to score a “yes.’”26 As the treating physiotherapist cannot be blinded to the treatment (strength training) being provided, all studies in this review will score “no” for this criterion.

f. Were co-interventions avoided or comparable? (Internal validity criterion) “Cointerventions should either be avoided in the trial design or similar between the index and control groups.”26 The study report should indicate this is the case, it should not be assumed. This should include a statement about other physical activities such as sports, as well as any activities provided as “therapy.”

g. Was the compliance acceptable in all groups? (Internal validity criterion) “The reviewer determines if the compliance to the interventions is acceptable, based on the reported intensity, duration, number and frequency of sessions for the index intervention and control intervention(s).”26 Omission of data from subjects unable to complete the full training schedule implies full compliance of the remaining subjects, and scores “yes” (although this is not an intention-to-treat analysis and will score “no” for item p). Make-up sessions within a reasonable time frame will count as compliance, and contribute to a “yes.” No statement about compliance with training sessions does not confer an assumed “yes,” but will score “unclear.”

h. Was the patient blinded for the intervention? (Internal validity criterion) ‘The reviewer determines if enough information about the blinding is given in order to score a “yes.’”26 As with criterion (e), blinding of subjects to the intervention is impossible in strength training studies, and all studies will score “no” for this criterion.

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Outcome Measurement

i. Was the outcome assessor blinded for the intervention? (Internal validity criterion) ‘The reviewer determines if enough information about the blinding is given in order to score a “yes’.”26 “The method will be regarded as appropriate if it is stated that ….the person doing the assessments …. could [not] identify the intervention being assessed.”24 In the case of noncontrolled studies, blinding of the assessor to subjects’ previous scores will confer “yes” for this criterion. This should be stated, not assumed.

j. Were the outcome measures relevant? (Internal validity criterion) Any objective outcome measures evaluating change in functional abilities, gait parameters, gross motor abilities, and lower limb strength measures are regarded as relevant in this review. Outcome measures must be both validated and reliable. However, if the study relies solely on outcome measures devised by the authors for that study, with no/little evidence of validity or reliability, this scores “unclear.”

k. Were adverse effects described? (Descriptive criterion) Historically, many pediatric physiotherapists have believed strength training would cause the adverse effect of increased spasticity; and there could be a risk of musculoskeletal injury during strength training in children and youth, both disabled and non-disabled. Therefore, it is important that study authors report the occurrence, or absence, or any adverse effects. No statement about adverse effects scores “no.” A clear statement, be it positive or negative, scores “yes.”

l. Was the withdrawal/drop-out rate described and acceptable? (Internal validity criterion) “Participants who were included in the study but did not complete the observation period or who were not included in the analysis must be described. The number and the reasons for withdrawal in each group must be stated. If there were no withdrawals, it should be stated in the article. If there is no statement on withdrawals, this item must be given no points.”24 ‘If the percentage of withdrawals and drop-outs does not exceed 20% for short-term follow-up and 30% for long-term follow-up and does not lead to substantial bias a “yes” is scored. (Note: these percentages are arbitrary, not supported by literature).’26

m1. Was a short-term follow-up measurement performed? (Descriptive criterion) The short-term follow-up will usually be at the end of the intervention period.

m2. Was a long-term follow-up measurement performed? (Descriptive criterion) The long-term follow-up should be at some later point, to evaluate the possible effects of detraining, and the natural course of growth, development, maturation, or possible deterioration.

n. Was the timing of the outcome assessment in both groups comparable? (Internal validity criterion) “Timing of outcome assessment should be identical for all intervention groups and for all important outcome assessments.”26 This is the timing of the outcome assessments in relation to the timing of the intervention. Staggered recruitment is acceptable, provided each subject is assessed at the same time points in relation to the intervention.

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Statistics

o. Was the sample size for each group described? (Statistical criterion) Is the sample described such that the reviewer can envisage where in the population this sample comes from? This item requires the description of the sample, as distinct from the description of the population required for item (a).

p. Did the analysis include an intention-to-treat (ITT) analysis? (Internal validity criterion) “All randomized patients are reported/analyzed in the group they were allocated to by randomization for the most important moments of effect measurement (minus missing values) irrespective of noncompliance and cointerventions.”26 If no subjects were lost, no ITT analysis is necessary and this item scores “yes.” A description of any subjects lost to follow-up is not, however, the equivalent of ITT analysis. For noncontrolled studies, the inclusion of data from any noncompliant subjects is required to score a “yes” for this criterion.

q. Were point estimates and measures of variability presented for the primary outcome measurements? (Statistical criterion) For outcome measures, the median value, interquartile range, and maximum/minimum values should be presented as a box plot; or the mean value and standard deviation given if the data is normally distributed.27

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Keywords:

adolescent; cerebral palsy; child; exercise therapy; human movement system; muscle strength; physical therapy; state of the art review; treatment outcomes

© 2008 Lippincott Williams & Wilkins, Inc.

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