Abstract: Dextromethorphan is an over-the-counter dissociative agent of increasing popularity as a drug of abuse among younger adolescents. The drug produces a range of toxicities depending upon either the dose or the components of the specific formulation that was ingested. Most cases improve with supportive care alone, but severely intoxicated patients may require significant attention. Because dextromethorphan is misused primarily by younger adolescents, the early identification and treatment of dextromethorphan abuse may be important in preventing broader substance abuse in these children. Consequently, it is important for clinicians to recognize, treat, and appropriately refer those who present with intoxication from this drug.