The use of a combination of ketamine and propofol (ketofol) for procedural sedation and analgesia in the emergency department setting shows promise as an agent that may minimize adverse effects of ketamine or propofol as single agents. This article provides a summary of current literature regarding ketofol. It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia.
Assistant Professor (Alletag and Auerbach), *University of Texas Southwestern Medical Center, Dallas, TX; and Associate Professor (Baum), †School of Medicine, Yale University, New Haven, CT.
The authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interest in, any commercial organizations pertaining to this educational activity.
Reprints: Michelle J. Alletag, MD, University of Texas Southwestern Medical Center, Section of Pediatric Emergency Medicine, 1935 Medical District Drive, Mail Code E2.03, Dallas, TX 75235 (e-mail: Michelle.Alletag@utsouthwestern.edu).