Successful Intravenous Thrombolysis in a 14-Year-Old Boy With Ischemic StrokeSampaio, Isabel MD*; Abecasis, Francisco MD†; Quintas, Sofia MD‡; Moreno, Teresa MD‡; Camilo, Cristina MD†; Vieira, Marisa MD†; Pinho e Melo, Teresa MD§; Correia, Manuela MD†Pediatric Emergency Care: June 2011 - Volume 27 - Issue 6 - p 541-543 doi: 10.1097/PEC.0b013e31821dc6e8 Illustrative Cases Abstract Author Information We report a healthy 14-year-old boy with an acute left middle cerebral artery stroke, treated 2 hours after the onset of symptoms with intravenous recombinant tissue plasminogen activator (r-TPA). Recanalization of the middle cerebral artery was documented with transcranial Doppler during the first 5 minutes of intravenous r-TPA perfusion, and progressive recovery of the neurological deficits occurred. Although lack of evidence regarding safety and efficacy in children precludes the recommendation of systematic use of r-TPA in pediatric stroke, we propose that this option should be considered and discussed with the parents, especially in older children presenting within 3 hours in centers with experience in adult thrombolysis. From the *Pediatrics Department; †Pediatric Intensive Care Unit and ‡Pediatric Neurology Division, Pediatrics Department; and §Neurology Division, Neurosciences Department, Hospital de Santa Maria, Lisbon, Portugal. Reprints: Isabel Sampaio, MD, Rua Cidade de Rabat n° 52 5° esq, 1500 Lisboa, Portugal (e-mail: firstname.lastname@example.org). © 2011 Lippincott Williams & Wilkins, Inc.