Pediatric Emergency Care

Skip Navigation LinksHome > December 2010 - Volume 26 - Issue 12 > Chickenpox Is Not Always Benign: Postvaricella Purpura Fulmi...
Pediatric Emergency Care:
doi: 10.1097/PEC.0b013e3181fe91cd
Illustrative Cases

Chickenpox Is Not Always Benign: Postvaricella Purpura Fulminans Requires Prompt and Aggressive Treatment

Fluri, Simon MD*; Kaczala, Gregor W. MD†; Leibundgut, Kurt MD‡; Alberio, Lorenzo MD§

Collapse Box


We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.

© 2010 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.