Pediatric Emergency Care

Skip Navigation LinksHome > December 2010 - Volume 26 - Issue 12 > Chickenpox Is Not Always Benign: Postvaricella Purpura Fulmi...
Pediatric Emergency Care:
doi: 10.1097/PEC.0b013e3181fe91cd
Illustrative Cases

Chickenpox Is Not Always Benign: Postvaricella Purpura Fulminans Requires Prompt and Aggressive Treatment

Fluri, Simon MD*; Kaczala, Gregor W. MD†; Leibundgut, Kurt MD‡; Alberio, Lorenzo MD§

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Abstract

We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.

© 2010 Lippincott Williams & Wilkins, Inc.

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