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Novel Influenza A(H1N1): Clinical Presentation, Diagnosis, and Management

Jain, Rini MD; Goldman, Ran D. MD

doi: 10.1097/PEC.0b013e3181c3c8f8
CME Review Articles

In April 2009, a novel influenza A(H1N1) virus was identified in Mexico and has since spread rapidly worldwide. The unique genetic and antigenic features of this virus have resulted in a high incidence of infection, with an epidemiologic profile that is different from that of previous seasonal influenza infections. As a consequence, a surge of pediatric patients has been presenting to emergency departments and physician's offices across the country during this 2009-2010 flu season. This article summarizes the clinical presentation of novel influenza A(H1N1) infection and identifies patient groups who are at high risk of severe disease. It also presents guidelines from the United States Centers for Disease Control and Prevention and the World Health Organization on diagnostic testing and management of patients with H1N1 infection, including postexposure prophylaxis and identification of patients who should be vaccinated.

Fellow (Jain) and Associate Professor (Goldman), Division of Pediatric Emergency Medicine, Department of Pediatrics, University of British Columbia, Child & Family Research Institute, Vancouver, British Columbia, Canada.

Reprints: Ran D. Goldman, MD, Division of Pediatric Emergency Medicine, BC Children's Hospital, Department of Pediatrics, University of British Columbia, Child & Family Research Institute, Vancouver, British Columbia, Canada (e-mail: rgoldman@cw.bc.ca).

Unless otherwise noted below, each faculty's spouse/life partner (if any) has nothing to disclose.

The authors have disclosed that they have no significant relationship with or financial interests in any commercial companies that pertain to this educational activity.

All staff in a position to control the content of this CME activity have disclosed that they have no financial relationships with, or financial interests in, any commercial companies pertaining to this educational activity.

Lippincott CME Institute has identified and resolved all faculty conflicts of interest regarding this educational activity.

© 2009 Lippincott Williams & Wilkins, Inc.