Kochanek, Patrick M. MD, FCCM; Carney, Nancy PhD; Adelson, P. David MD, FACS, FAAP; Ashwal, Stephen MD; Bell, Michael J. MD; Bratton, Susan MD, MPH, FAAP; Carson, Susan MPH; Chesnut, Randall M. MD, FCCM, FACS; Ghajar, Jamshid MD, PhD, FACS; Goldstein, Brahm MD, FAAP, FCCM; Grant, Gerald A. MD; Kissoon, Niranjan MD, FAAP, FCCM; Peterson, Kimberly BSc; Selden, Nathan R. MD, PhD, FACS, FAAP; Tong, Karen A. MD; Tasker, Robert C. MBBS, MD, FRCP; Vavilala, Monica S. MD; Wainwright, Mark S. MD, PhD; Warden, Craig R. MD, MPH, FAAP, FACEP
From Critical Care Medicine (PMK, MJB), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Medical Informatics and Clinical Epidemiology (NC, SC, KP), Oregon Health & Science University, Portland, OR; Barrow Neurological Institute at Phoenix Children's Hospital (PDA), and Pediatric Neurosurgery/ Children' Neurosciences (PDA), Phoenix, AZ; Division of Child Neurology, Department of Pediatrics (SA) and Section of Neuroradiology (KAT), Loma Linda University School of Medicine, Loma Linda, CA; Pediatric Critical Care Medicine (SB), University of Utah School of Medicine, Salt Lake City, UT; Department of Neurological Surgery (NRS), Oregon Health & Science University, Portland, OR; Orthopedics and Sports Medicine (RMC), University of Washington School of Medicine, Seattle, WA; Neurological Surgery (JG), Weill Cornell Medical College; President of the Brain Trauma Foundation (JG), New York, NY; Translational Science (BG), Ikaria, Inc., Clinton, NJ; Pediatrics (BG), University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ; Surgery and Pediatrics (GAG), Duke University School of Medicine, Durham, NC; Pediatrics and Emergency Medicine (NK), British Columbia's Children's Hospital, University of British Columbia, Vancouver, BC; Neurocritical Care (RCT), Children's Hospital Boston; Neurology and Anesthesia (RCT), Harvard Medical School, Boston, MA; Anesthesiology and Pediatrics (MSV), University of Washington School of Medicine, Seattle, WA; Molecular Pharmacology and Biological Chemistry (MSW), Northwestern University Feinberg School of Medicine, Chicago, IL; Emergency Medicine and Pediatrics (CRW), and Pediatric Emergency Services (CRW), Oregon Health & Science University/Doernbercher Children's Hospital, Portland, OR.
Funding was provided by the Brain Trauma Foundation and partial funding from the Charles Maddock Foundation.
The authors have not disclosed any potential conflicts of interest.
For information regarding this article, E-mail: firstname.lastname@example.org
Strength of Recommendations: Weak.
Quality of Evidence: Low, from poor and moderate-quality class III studies.
A. Level I
There are insufficient data to support a level I recommendation for this topic.
B. Level II
There are insufficient data to support a level II recommendation for this topic.
C. Level III
Decompressive craniectomy (DC) with duraplasty, leaving the bone flap out, may be considered for pediatric patients with traumatic brain injury (TBI) who are showing early signs of neurologic deterioration or herniation or are developing intracranial hypertension refractory to medical management during the early stages of their treatment.
II. EVIDENCE TABLE (see Table 1)
DC in the setting of TBI is a controversial procedure that has recently become widely considered as a treatment option. It may be performed concomitantly with the removal of a mass lesion to either treat observed brain swelling or act as prophylaxis of anticipated swelling (secondary DC). Alternatively, it may be performed as a standalone procedure for the purpose of treating cerebral herniation or established intracranial hypertension, wherein the timing of the decompression may be predicated on the clinical examination, course of neurologic deterioration, initial degree of intracranial pressure (ICP) elevation, or the resistance of that elevation to various thresholds of medical treatment (primary DC). These two conditions of employment are actually quite different and it is the second (DC as a primary treatment for cerebral swelling) that is the focus on this section.
The nature of the procedure varies widely. It may consist of uni- or bilateral subtemporal decompressions, hemispheric craniectomies of varying sizes (from relatively small to quite expansive), circumferential craniectomy, or bifrontal craniectomy. The choice of procedure may depend on the underlying pathology, as demonstrated on computed tomography imaging, or may simply be focused on developing the maximum possible compliance compartment. The management of the underlying dura also may vary, ranging from leaving it intact through simple scoring to opening it widely (with or without expansive duraplasty). Furthermore, the treatment of the dura may vary independently with the choice of bony decompressive procedure.
With respect to the use of DC for ICP control in adults, two randomized controlled trials were underway, the DECRA Trial (1) (international multicenter randomized controlled trial (on Early Decompressive Craniectomy in Traumatic Brain Injury), which recently reported their findings (2) of reduced ICP but significantly worsened outcomes, and the RescueICP Trial (3) (randomized evaluation of surgery with craniectomy for uncontrollable elevation ICP). No similar studies are ongoing for the pediatric population.
For this update, MEDLINE was searched from 1996 through 2010 (Appendix B for search strategy), and results were supplemented with literature recommended by peers or identified from reference lists. Of 20 potentially relevant studies, seven new studies were included as evidence for this topic.
V. SCIENTIFIC FOUNDATION
Eight class III studies met the inclusion criteria for this topic and provide evidence to support the recommendations (4–11). These studies vary in critical areas such as their selection criteria for DC, the DC techniques used, and their outcome parameters. In addition, none of them defined the study population to an extent adequate to allow rigorous interstudy comparisons. The lack of internal comparison groups or matched controls weakens the analyses that can be applied.
Is Decompressive Craniectomy Effective in Lowering ICP?
The issue with respect to the efficacy of DC in lowering ICP is not the statistical significance of the change in ICP from before surgery to the postoperative state but rather it is in lowering severely or medically intractable ICP elevation with respect to the treatment threshold such that intracranial hypertension is no longer encountered (optimal outcome) or is easily controlled after surgery.
A study by Hejazi et al (6) was performed investigating early unilateral or bilateral DC with duraplasty for Glasgow Coma Scale score of 3–5 in seven pediatric patients with TBI within 70 mins from trauma resulting from “massive” bilateral or unilateral swelling, compressed supratentorial ventricular spaces, and perimesencephalic cisterns. The DC was frontotemporal and did not include the parietal and occipital regions. A low craniectomy was performed in all patients to decompress the brainstem. The initial ICP exceeded 45 mm Hg in all patients. In six of the seven, ICP remained <20 mm Hg after surgery. Persistent intracranial hypertension (although not to the level of preoperative) in the one patient was controlled with medical therapy. This suggests that DC might be effective in controlling ICP.
A study by Ruf et al (9) was also performed on unilateral or bilateral DC with duraplasty when the ICP exceeded 20 mm Hg for >30 mins in six pediatric patients with severe TBI. In five of the six, ICP remained <20 mm Hg after surgery. Persistent intracranial hypertension in the sixth patient prompted a return to surgery for a contralateral DC, which resulted in sustained ICP control. This suggests that DC might be effective in controlling ICP. Unfortunately, further information on how the choice of operation was made in these patients is lacking.
A study by Kan et al (8) was performed to investigate a large unilateral DC with duraplasty in pediatric patients with TBI, either in conjunction with the removal of a mass lesion (45 patients) or primarily for brain swelling (six patients, five for refractory ICP >25 mm Hg, and one for herniation). The six patients relevant to this topic were very severely injured with low admission Glasgow Coma Scale scores, evidence of herniation, or severe secondary insults common among them. For these six patients, three of the four who received postoperative ICP monitoring had sustained ICP values <20 mm Hg. The fourth had intracranial hypertension requiring further treatment. Five of the six patients died.
A study by Rutigliano et al (10) was performed which was a retrospective case series of six patients with TBI of age <20 yrs who underwent DC for elevated ICP (without a specified definition), which was refractory to guidelines-based treatment. Five of these patients were <18 yrs of age and could be analyzed separately. They performed wide bifrontal/biparietal craniectomies with duraplasty. Four of the five had no postoperative ICP elevations. The fifth patient required a return to surgery for intracranial hypertension whereupon débridement of the contused brain resulted in resolution.
A study by Jagannathan et al (7) was performed as a retrospective case series of 23 patients with TBI of age <20 yrs who underwent DC for initial mass lesion requiring evacuation or elevated ICP (>20 mm Hg), which was refractory to guidelines-based treatment. Twenty-one of these patients were <18 yrs of age and could be analyzed separately. They performed wide bifrontal/biparietal craniectomies with duraplasty and sectioning of the falx or unilateral DC if there was a mass lesion or unilateral swelling. Ten of the 23 patients underwent early DC, 11 had later DC, and two even later as a result of medical instability. Mean ICP reduced from 30 mm Hg preoperatively to 18 mm Hg postoperatively. Nineteen of 23 patients had control of postoperative ICP elevations with maximal medical management. Two patients continued to have refractory ICP.
A study by Cho et al (4) was a case series of 23 children <2 yrs of age presenting with nonaccidental trauma. Children were included based on their ICP regardless of their presenting level of consciousness. A subgroup of 13 patients with a Children's Coma Score equivalent to severe on the Glasgow Coma Scale, and ICP values >30 mm Hg, were treated medically (n = 4) or with DC (n = 9) based on either family wishes or being admitted before DC became a routine part of treatment for this disease. On the nine surgical patients, bifrontal DC was performed for diffuse swelling or large unilateral frontotemporoparietal DCs for unilateral hemispheric swelling. They included a section of the anterior sagittal sinus and an expansive duraplasty. The decompression was performed within 24 hrs of injury in the majority. In the surgical group, DC lowered the mean ICP measurements from 54.9 mm Hg to 11.9 mm Hg.
In summary, it appears that DC may be effective in lowering ICP to below the threshold for treatment in patients refractory to medical management. This limited conclusion would add some support to choosing to perform DC for ICP control when intracranial hypertension is resistant to nonsurgical management and the ICP levels maintained are considered hazardous to the patient.
Does Decompressive Craniectomy Improve Clinical Outcomes?
This section focuses on whether DC performed for severe or intractable intracranial hypertension or clinical herniation is associated with a beneficial influence on outcome.
All of the studies in this section are retrospective case series. All used retrospectively collected data, except for the Rutigliano et al (10) study that used a prospectively collected database, which was not designed specific to the question of DC. None of them have internal or matched external controls and there were no randomized controlled trials. Common to all of these studies is the absence of sufficient data on the injury characteristics of the study group to predict their outcomes independent of the surgical decompression using predictive modeling.
A study by Hejazi et al (6) reported that all of the patients with early DC had a “complete recovery” although this is not defined. There was no mortality and complication rate was low with only subdural effusions in four of seven.
A study by Figaji et al (5) reported “early [postoperative] clinical improvement” in their decompressed patients. All five cases had Glasgow Outcome Scale scores of 4–5 at 14- to 40-month follow-up. The patients had not had preoperative ICP monitoring and had DC performed for clinical deterioration. The authors felt that the outcomes were better than expected given that each of the patients had an initial Glasgow Coma Scale score ≤8, each had a documented secondary deterioration, which was believed to be the result of raised ICP, pupillary abnormalities were seen in four, and all demonstrated obliteration of the perimesencephalic cisterns (diffuse injury III and IV).
A study by Ruf et al (9) studied six pediatric patients with TBI undergoing DC for refractory ICP >20 mm Hg. One of the six was a posterior fossa DC to treat swelling from a cerebellar contusion. At 6 months, all patients had survived, three being described as “normal” and the others having mild-to-moderate residual deficits.
A study by Rutigliano et al (10) described six pediatric patients with TBI who underwent DC. Five of these patients were <18 yrs of age. A large bilateral frontoparietal DC with duraplasty was performed for “elevated ICP” refractory to tier 1 and tier 2 medical management. They reported early signs of clinical improvement and discharge Functional Independence Measurement scores of independent or minimal assistance for all five patients.
A study by Jagannathan et al (7) described 21 pediatric patients with TBI after undergoing DC either incidentally after evacuation of a mass lesion or for diffuse swelling refractory ICP to medical management. Eighteen of 23 were done for refractory ICP to maximal medical management, three of whom had pupillary changes and did not survive DC. They reported an overall 22% mortality rate despite ICP ≤20 mm Hg in two of the five patients who died. Mean follow-up was 62 months (range, 11–126 months) and the mean Glasgow Outcome Scale score was 4.2 (range, 1–5). The mean score on the quality-of-life questionnaires was 4 (maximum, 5) in the ability to perform activities of daily living, general cognition, interpersonal behavior, and emotional behavior (range, 1–4.75).
In the Cho et al (4) case series, children <2 yrs of age with severe TBI from nonaccidental trauma and ICP values >30 mm Hg were treated with medically (n = 4) or with decompressive craniotomy (n = 9). For the medically treated group, scores on the Children's Outcome Scale (COS), measured at a mean of 3.2 yrs (range, 6 months to 6 yrs), revealed two dead (COS 5) and two vegetative (COS 4). For the surgical group, two patients had an “excellent” recovery (COS 1), two had a moderate recovery (COS 2), four had severe disability (COS 3), and one was vegetative. Notably, although DC was performed based on ICP elevation alone, a mean of 32 mL of subdural blood was removed during the surgery.
Two studies reported less favorable outcomes (8, 11). A study by Skoglund et al (11) studied 19 patients with TBI, of whom eight were <18 yrs, treated with DC for either refractory ICP >20 mm Hg or acute neurologic deterioration immediately after trauma with computed tomography scan showing diffuse edema. All patients were medically managed using the Lund approach. Five of the eight pediatric patients had neurologic deterioration or pupillary changes at the time of surgery. Outcome at ≥1 yr after surgery was three patients with Glasgow Outcome Scale score of 5, one with Glasgow Outcome Scale score of 4, three with Glasgow Outcome Scale score of 3, and one death.
A study by Kan et al (8) described 51 pediatric patients with TBI undergoing DC, although the craniectomy was incidental to surgery to evacuate a mass lesion in 45. Five cases were done for refractory ICP >25 mm Hg and the sixth for clinical herniation. These patients were very severely injured. Three were Glasgow Coma Scale score 3 on admission, three were bilaterally fixed and dilated, and two others had a unilateral fixed and dilated pupil. The sixth patient presented with profound hypotension. They reported an 83% mortality rate despite ICP ≤20 mm Hg in three of the four patients monitored after surgery. Five of the six patients died.
Given the paucity of descriptive statistics contained within these studies, it is impossible to accurately compare the patients studied between these various papers. Adding in the differences in trigger criteria for DC, variations in DC technique, and the wide variations in outcome measurements, no more than simple, qualitative summaries may be made. Given the severity of injury of these children and the physiological abnormalities required to become candidates for DC, cautious interpretation of these outcomes suggests that DC may be effective in improving outcome in patients with medically intractable intracranial hypertension.
VI. INFORMATION FROM OTHER SOURCES
A. Indications From the Adult Guidelines
The Guidelines for the Surgical Management of TBI (12), published in 2006, found no class I or II evidence on which to base level I or II recommendations. The level III-equivalent recommendations with respect to DC were based on class III literature, the most prominent of which were the reports of Polin et al (13) and Taylor et al (14) (briefly reviewed subsequently).
The recommendations from the adult guidelines regarding DC were:
* Bifrontal DC within 48 hrs of injury is a treatment option for patients with diffuse, medically refractory posttraumatic cerebral edema and resultant intracranial hypertension.
* Decompressive procedures, including subtemporal decompression, temporal lobectomy, and hemispheric DC, are treatment options for patients with refractory intracranial hypertension and diffuse parenchymal injury with clinical and radiographic evidence for impending transtentorial herniation.
* Of note, the recently completed DECRA study by Cooper et al (2) for adults with diffuse severe TBI showed that ICP could be effectively reduced with early bifrontotemporoparietal DC but, interestingly, outcomes were worse in the surgery group than the clinical management group alone.
B. Information Not Included as Evidence
Indications From the 2009 Cochrane Review on Decompressive Craniectomy.
In the 2009 update of the Cochrane Review on DC (15), the author found only one publication of sufficient rigor to include, that of Taylor et al (14), which studied a pediatric TBI group. It was concluded that “despite the wide confidence interval for death and the small sample size of this one identified study, the treatment may be justified in patients below the age of 18 yrs when maximal medical treatment has failed to control ICP.” With respect to the current evidence report, however, this paper must be excluded as a result of its inclusion of patients with admissions scores above the cutoff (≤8).
Eight small class III case series suggest that large decompressive surgeries with duraplasty may be effective in reversing early signs of neurologic deterioration or herniation, and in treating intracranial hypertension refractory to medical management, and that these effects may be correlated with improving outcomes in the critically ill pediatric patients who develop such indications. Limited evidence suggests that duraplasties, when done, should be large, and consideration should be given to removing the bone rather than “floating” it in situ. There is insufficient evidence to allow defining the patient characteristics that either 1) optimize the beneficial effects of these procedures or 2) render them ineffective.
VIII. KEY ISSUES FOR FUTURE INVESTIGATION
* A primary focus on future research should be performing a randomized controlled trial on DC as a method of controlling increased ICP in pediatric patients with TBI.
* Given the infrequency with which pediatric patients with TBI are admitted to any individual center, it would be very useful to develop a prospective pediatric TBI database to facilitate class II investigations into many of the variables relevant to DC (such as timing, size and placement, and technique), which are unlikely to ever be subject to class I study.
* It would be very useful if the investigators involved in the two adult DC trials, the DECRA trial (1) and the Rescue ICP trial (3), both of which enrolled patients overlapping with the pediatric age group, would parse out this group for separate subgroup analysis of efficacy and technical details. It would be valuable to design or determine standardized and practical techniques to quantify the physiological changes induced by DC, both as a clinically useful measure of efficacy and as a research parameter.
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