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Perioperative Steroids Administration in Pediatric Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials*

Scrascia, Giuseppe MD1; Rotunno, Crescenzia BSc1; Guida, Pietro PhD1; Amorese, Lillà MD1; Polieri, Debora MD2; Codazzi, Daniela MD3; Paparella, Domenico MD1

Pediatric Critical Care Medicine: June 2014 - Volume 15 - Issue 5 - p 435–442
doi: 10.1097/PCC.0000000000000128
Cardiac Intensive Care

Objective: To evaluate the effects of prophylactic perioperative corticosteroid administration, compared with placebo, on postoperative mortality and clinical outcomes (renal dysfunction, duration of mechanical ventilation, and ICU length of stay) in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass.

Data Sources: MEDLINE and Cochrane Library were screened through August 2013 for randomized controlled trials in which perioperative steroid treatment was adopted.

Study Selection: Included were randomized controlled trials conducted on pediatric population that reported clinical outcomes about mortality and morbidity.

Data Extraction: Eighty citations (PubMed, 48 citations; Cochrane, 32 citations) were identified, of which 14 articles were analyzed in depth and six articles fulfilled eligibility criteria and reported mortality data (232 patients), two studies reported ICU length of stay and mechanical ventilation duration (60 patients), and two studies reported renal dysfunction (49 patients).

Data Synthesis: A nonsignificant trend of reduced mortality was observed in steroid-treated patients (11 [4.7%] vs 4 [1.7%] patients; odds ratio, 0.41; 95% CI, 0.14–1.15; p = 0.089). Steroids had no effects on mechanical ventilation time (117.4 ± 95.9 hr vs 137.3 ± 102.4 hr; p = 0.43) and ICU length of stay (9.6 ± 4.6 d vs 9.9 ± 5.9 d; p = 0.8). Perioperative steroid administration reduced the prevalence of renal dysfunction (13 [54.2%] vs 2 [8%] patients; odds ratio, 0.07; 95% CI, 0.01–0.38; p = 0.002).

Conclusion: Despite a demonstrated attenuation of cardiopulmonary bypass–induced inflammatory response by steroid administration, a systematic review of randomized controlled trials performed so far reveals that steroid administration has potential clinical advantages (lower mortality and significant reduction of renal function deterioration). A larger prospective randomized study is needed to verify clearly the effects of steroid prophylaxis in pediatric patients.

1Division of Cardiac Surgery, Department of Emergency and Organ Transplant, University of Bari “Aldo Moro,” Bari, Italy.

2Pediatric Cardiac Anesthesia/Intensive Care Unit Department of Medical and Surgical Pediatric Cardiology, “Bambino Gesù” Children’s Hospital, Rome, Italy.

3Department of Anesthesia, Intensive and Palliative Care, Foundation-I.R.C.C.S. “National Institute of cancer,” Milan, Italy.

* See also p. 492.

The authors have disclosed that they do not have any potential conflicts of interest.

For information regarding this article, E-mail: domenico.paparella@uniba.it

©2014The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies