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Pediatric Critical Care Medicine:
doi: 10.1097/PCC.0b013e31828a7f9b
Online Laboratory Investigations

Cardiac Dysfunction in Pneumovirus-Induced Lung Injury in Mice

Bem, Reinout A. MD, PhD1; van den Berg, Elske MD1; Suidgeest, Ernst MSc2; van der Weerd, Louise MD, PhD2,3; van Woensel, Job B. M. MD, PhD1; Grotenhuis, Heynric B. MD, PhD2,4

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Objective: To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.

Design: Experimental animal study.

Setting: Animal laboratory.

Subjects: C57Bl/6 mice.

Intervention: Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.

Measurements and Main Results: Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.

Conclusions: These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.

©2013The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies


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