Objective: To provide an updated overview of critical pertussis to the pediatric critical care community and describe a study of critical pertussis recently undertaken.
Setting: The six sites, seven hospitals of the Collaborative Pediatric Critical Care Research Network, and 17 outside sites at academic medical centers with pediatric intensive care units.
Results: Despite high coverage for childhood vaccination, pertussis causes substantial morbidity and mortality in US children, especially among infants. In pediatric intensive care units, Bordetella pertussis is a community-acquired pathogen associated with critical illness and death. The incidence of medical and developmental sequelae in critical pertussis survivors remains unknown, and the appropriate strategies for treatment and support remain unclear. The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study has begun to evaluate critical pertussis in a prospective cohort.
Conclusion: Research is urgently needed to provide an evidence base that might optimize management for critical pertussis, a serious, disabling, and too often fatal illness for U.S. children and those in the developing world.
From the University of Utah (JSB), Salt Lake City, UT; Eunice Kennedy Shriver National Institute of Child Health and Human Development (TLJ, CEN), National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Mattel Children's Hospital UCLA (RH), Los Angeles, CA;. Children's Hospital of Michigan (KM), Detroit, MI; the University of Tennessee Health Science Center (KJSA), Memphis, TN;. Children's National Medical Center (JTB), Washington, DC; Seattle Children's Hospital (JZ), Seattle, WA; Children's Hospital of Pittsburgh (JC), Pittsburgh, PA; Children's Hospital of Los Angeles (CJLN), Los Angeles, CA; University of Virginia Children's Hospital (DFW), Charlottesville, VA; Children's Hospital of Arkansas (RCS), Little Rock, AR; Phoenix Children's Hospital (MMP), Phoenix, AZ; and The Pennsylvania State University (EH), University Park, PA.
The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
The authors have not disclosed any potential conflicts of interest.
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