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Challenging epithelioid mesenchymal neoplasms: mimics and traps

Cacciatore, Matilde; Dei Tos, Angelo P.

doi: 10.1097/PAT.0000000000000063
Soft Tissue Pathology

Summary: Epithelioid mesenchymal malignancies represent a major diagnostic challenge. Epithelioid morphology can be observed in a variety of soft tissue neoplasms, however there exist specific subtypes in which an epithelioid apperance constitutes the most distinctive morphological feature. Moving from epithelioid sarcoma of Enzinger (the prototype of sarcoma with epithelioid morphology), this review will focus on the most relevant entities: namely epithelioid haemangioendothelioma and angiosarcoma, pseudomyogenic haemangioendothelioma, epithelioid malignant peripheral nerve sheath tumour, epithelioid sclerosing fibrosarcoma, epithelioid pleomorphic liposarcoma, alveolar soft part sarcoma, and undifferentiated soft tissue sarcoma with epithelioid morphology. Differential diagnoses and major pitfalls will be discussed in detail.

Author Information

Departments of Oncology and Pathology, Treviso, Italy

Address for correspondence: Dr A. P. Dei Tos, Departments of Pathology and Oncology, General Hospital of Treviso, Piazza Ospedale, 1, I-31100 Treviso, Italy. E-mail:

Received 28 November, 2013

Accepted 2 December, 2013

© 2014 Royal College of Pathologists of Australasia

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