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Long term outcome of primary urothelial papilloma: a single institution cohort

Al Bashir, Samir1; Yilmaz, Asli1; Gotto, Geoffrey2; Trpkov, Kiril1

doi: 10.1097/PAT.0000000000000029
Anatomical Pathology

Summary: The aim of this study was to investigate the long term outcome of primary urothelial papilloma (UP).

We retrieved 41 primary UP, diagnosed between January 2000 and December 2009. Follow-up was obtained by searching pathology and clinical electronic databases.

Mean patient age was 57 years (range 30–84 years), with a male-to-female ratio of 1.9:1. Mean follow-up was 81 months (range 3–127 months). In 37 (90.2%) patients, no recurrence and/or progression were documented and no subsequent higher grade neoplasms were diagnosed. Three male patients were diagnosed with UP at 1, 31, and 43 months after the initial resection; the repeat diagnosis of UP at 1 month likely represented an incomplete resection. Thus, only two of 41 patients (4.9%) had a recurrent UP. One of these patients had a subsequent papillary urothelial neoplasm of low malignant potential (PUNLMP), 17 months after the recurrent UP (48 months after the initial UP). Only one additional male had a subsequent PUNLMP, 76 months after the initial UP. Thus, only two of 41 patients (4.9%) had a subsequent PUNLMP, both presenting with haematuria.

Primary UP does not progress to UC when diagnosed using strict criteria, when no previous or concurrent neoplasms are documented, and when complete initial resection is performed.

1Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary

2Division of Urology, University of Calgary, Calgary, Alberta, Canada

Address for correspondence: Dr K. Trpkov, Anatomical Pathology, Rockyview Hospital, Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, 7007 - 14 Street SW, Calgary, Alberta, Canada, T2V 1P9. E-mail: kiril.trpkov@cls.ab.ca

Received 19 July, 2013

Revised 23 October, 2013

Accepted 23 October, 2013

© 2014 Royal College of Pathologists of Australasia
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