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Multiple Endocrine Neoplasia Type 1: Problems and Pitfalls

Asa, Sylvia L. MD, PhD; Mete, Ozgur MD

Pathology Case Reviews:
doi: 10.1097/PCR.0000000000000024
Case Review

Abstract: The spectrum of pathology in multiple endocrine neoplasia type 1 encompasses many organs including not only the classic pituitary, parathyroid, and pancreas but also other sites that can create diagnostic dilemmas. We report a case in which the classic pathologies are present but the patient also developed endocrine tumors in unusual locations: thymus and lung. The definitions of hyperplasia, dysplasia, and neoplasia in the affected tissues differ, and the therapeutic implications of terminology and pathological findings are reviewed.

Author Information

From the Department of Pathology, Laboratory Medicine Program, University Health Network; and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Reprints: Sylvia L. Asa, MD, PhD, Department of Pathology, University Health Network, 200 Elizabeth St, 11th Floor, Toronto, Ontario, Canada M5G 2C4. E-mail:

The authors have no funding or conflicts to declare.

© 2014 by Lippincott Williams & Wilkins.