Mesenchymal Polyps of the Gastrointestinal TractPatil, Deepa T. MD; Goldblum, John R. MDAJSP: Reviews & Reports: March/April 2013 - Volume 18 - Issue 2 - p 87–92 doi: 10.1097/PCR.0b013e31828c335c Reviews Abstract Author Information Mesenchymal tumors of the gastrointestinal tract can rarely present as incidental polyps that are encountered during routine endoscopic investigations for nonspecific upper gastrointestinal symptoms or as a part of screening for colorectal neoplasms. The spectrum of lesions includes fatty, smooth muscle, neural, and vascular lesions, as well as gastrointestinal stromal tumors and inflammatory fibroid polyps. Because most mesenchymal proliferations that present as small polyps are benign in nature, this review discusses the clinical, pathological, and molecular characteristics of the most commonly encountered benign mesenchymal tumors, namely, leiomyoma, mucosal Schwann cell hamartoma, perineurioma, ganglioneuroma, granular cell tumor, and inflammatory fibroid polyp. From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH. Reprints: Deepa T. Patil, MD, Cleveland Clinic Department of Anatomic Pathology 9500 Euclid Ave, L-25 Cleveland, OH-44195. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts to declare. © 2013 Lippincott Williams & Wilkins, Inc.