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Atypical Small Acinar Proliferation in the Prostate

Meiers, Isabelle MD*; Kahane, Hillel MD, FCAP†; Bostwick, David G. MD, MBA, FCAP‡

doi: 10.1097/PCR.0b013e31817e18fa
Case Review

About 4% of contemporary prostate needle biopsies contain collections of small acini that are suspicious for cancer but which fall below the diagnostic threshold and are reported as atypical small acinar proliferation (ASAP) suspicious for but not diagnostic of malignancy. Prostate cancer has been identified in subsequent biopsies in the majority of cases of ASAP, indicating that this finding is a significant predictor of cancer. Identification of ASAP warrants repeat biopsy for concurrent or subsequent invasive carcinoma.

From the *Department of Pathology, University Hospital Lewisham, London, United Kingdom; †Bostwick Laboratories, Uniondale, New York; and ‡Bostwick Laboratories, Glen Allen, Virginia.

Reprints: David G. Bostwick, MD, MBA, FCAP, Bostwick Laboratories, 4355 Innslake Drive, Glen Allen, VA 23060. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.