Atypical Small Acinar Proliferation in the ProstateMeiers, Isabelle MD*; Kahane, Hillel MD, FCAP†; Bostwick, David G. MD, MBA, FCAP‡Pathology Case Reviews: July/August 2008 - Volume 13 - Issue 4 - pp 129-134 doi: 10.1097/PCR.0b013e31817e18fa Case Review Abstract Author Information About 4% of contemporary prostate needle biopsies contain collections of small acini that are suspicious for cancer but which fall below the diagnostic threshold and are reported as atypical small acinar proliferation (ASAP) suspicious for but not diagnostic of malignancy. Prostate cancer has been identified in subsequent biopsies in the majority of cases of ASAP, indicating that this finding is a significant predictor of cancer. Identification of ASAP warrants repeat biopsy for concurrent or subsequent invasive carcinoma. From the *Department of Pathology, University Hospital Lewisham, London, United Kingdom; †Bostwick Laboratories, Uniondale, New York; and ‡Bostwick Laboratories, Glen Allen, Virginia. Reprints: David G. Bostwick, MD, MBA, FCAP, Bostwick Laboratories, 4355 Innslake Drive, Glen Allen, VA 23060. E-mail: email@example.com. © 2008 Lippincott Williams & Wilkins, Inc.