The Pancreas

Biology, Pathobiology, and Disease

Second Edition

Vay Liang W. Go, M.D.
Department of Medicine
University of California
Los Angeles School of Medicine
Los Angeles, California

Eugene P. DiMagno, M.D.
Department of Medicine
Mayo Medical School
Rochester, Minnesota

Jerry D. Gardner, M.D.
Department of Internal Medicine
Saint Louis University School of Medicine
St. Louis, Missouri

Emanuel Lebenthal, M.D.
Department of Pediatrics
Hahnemann University
Philadelphia, Pennsylvania

Howard A. Reber, M.D.
Department of Surgery
University of California
Los Angeles School of Medicine
Los Angeles, California

George A. Scheele, M.D.
Department of Medicine
Harvard Medical School
Boston, Massachusetts

The classic textbook, “The Pancreas: Biology, Pathobiology and Diseases,” published by Raven Press in 1993 is now available in its entirety online on our journal’s website. This book summarizes the state of the art of our disciplines in biology, pathobiology and diseases of pancreas up to 1990. The articles that appear in the journal Pancreas, which started publishing in 1986, has provided most of the progress and advances in the field since then. The book is an excellent companion and provides continuity in the advances of pancreatology. We are grateful to our publisher, Lippincott Williams & Wilkins, for providing all the chapters of the book in open access and for providing additional references and historical perspective of our field.

Vay Liang W. (Bill) Go, M.D.

Contents

 

Table of Contents

Contributors…………………………………………………………………………………………... ix

Preface to the First Edition ………………………………………………………………………... xiii

Preface........................................................................................................................ xv

Acknowledgments………………………………………………………………………………….... xvii

 

Biology

  1. Anatomy of the Pancreas…………………………………………………………………..… 1
    Dale E. Bockman
  2. Fine Structure of the Human Exocrine Pancreas...................................................... 9
    Horst F. Kern
  3. Differentiation and Development of the Pancreas in Animals………………………...…... 21
    Sherwood Githens
  4. Prenatal and Postnatal Development of the Human Exocrine Pancreas…………........  57
    P. C. Lee and Emanuel Lebenthal
  5. Replication and Regeneration of the Pancreas…………………………………………..… 75
    Hans-Peter Elsässer, Guido Adler, and Horst F. Kern
  6. Transgenic Analysis of Pancreatic Function and Development……………….…..….….. 87
    Raymond J. MacDonald and Galvin H. Swift
  7. Regulation of Pancreatic Gene Expression in Response to Hormones and
    Nutritional Substrates
    …………………………….....................…………………..…..… 103
    George A. Scheele
  8. Cellular Compartmentation, Protein Processing, and Secretion in the
    Exocrine Pancreas
    ………………………………………………………………………….... 121
    George A. Scheele and Horst F. Kern
  9. Receptors for Secretagogues on Pancreatic Acinar Cells……………………………….. 151
    Jerry D. Gardner and Robert T. Jensen
  10. Stimulus-Secretion Coupling in Pancreatic Acinar Cells…………………………….…... 167
    John A. Williams and David I. Yule
  11. Electrophysiology of Acinar Cells…………………………………………………………... 191
    0. H. Petersen
  12. Pancreatic Secretory Enzymes ………………………………………………………..…... 219
    Heinrich Rinderknecht
  13. Lithostathine…………………………………………………………………………….........  253
    J. C. Dagorn
  14. The Use of Two-Dimensional Gel Electrophoresis and High-Performance
    Liquid Chromatography for the Analysis of Pancreatic Juice
    …………………….....…… 265
    P.J. Padfield and George A. Scheele
  15. Human Exocrine Pancreatic Enzyme Secretion....................................................... 275
    Eugene P. DiMagno and Peter Layer
  16. Pancreatic Duct Cell Secretion: Control and Mechanisms of Transport…………...…… 301
    R. M. Case and B. E. Argent
  17. Pancreatic Mucins ............................................................................................... 351
    Richard S. Metzgar, Michael A. Hollingsworth, and Bernard Kaufman
  18. Extracellular Matrix as a Regulator of Epithelial Polarity, Cell Growth, and
    Tissue Pattern............
    ……………………………………………………………………….. 369
    Donald E. Ingber
  19. Neural Regulation of Pancreatic Exocrine Function……...…………...………..………... 381
    Jens Juul Holst
  20. Hormonal Control of Pancreatic Exocrine Secretion…………………………………….... 403
    William Y Chey
  21. Neurohormonal Control of Pancreatic Enzyme Secretion in Animals.......................... 425
    Manfred V. Singer
  22. Interdependence of Nutrition and Exocrine Pancreatic Function................................. 449
    C. S. Pitchumoni and George A. Scheele
  23. Luminal Digestion of Fats …………………………………………………….......…………. 475
    Bengt Borgström

Experimental Models

  1. Experimental Acute Pancreatitis: Studies of the Early Events that Lead to Cell Injury................................................................................................................... 489
    Michael L. Steer and Ashok K. Saluja
  2. Cerulein-Induced Pancreatitis................................................................................. 501
    Fred S. Gorelick, Guido Adler, and Horst F. Kern
  3. Permeability Characteristics of the Main Pancreatic Duct in Cats: Models of
    Acute and Chronic Pancreatitis
    ……………………………………...………………..…….. 527
    Howard A. Reber, Guido Adler, Nariman Karanjia, and Adam Widdison
  4. Experimental Models of Exocrine Pancreatic Tumors …………..……………………….. 551
    Daniel S. Longnecker
  5. Cell Lines of the Human and Rodent Exocrine Pancreas...…....………………………... 565
    Marsha L. Frazier and Daniel S. Longnecker

Pancreatitis

  1.  Pancreatitis Definitions and Classification…………………………………………….…… 575
    Martin Sarner
  2. Etiology and Pathophysiology of Acute Pancreatitis…………………………………….... 581
    Michael L. Steer
  3. Medical Management of Acute Pancreatitis and Complications……………………....... 593
    Peter A. Banks
  4. Diagnosis of Acute Pancreatitis………………………………………………….………….. 613
    Michael D. Levitt and John H. Eckfeldt
  5. Acute Pancreatitis: Surgical Management……………………………………………........ 637
    John H. C. Ranson
  6. Pancreatic Abscess………………………………………………...…........……………….. 649
    Edward L. Bradley III and Andrew L. Warshaw
  7. Chronic Pancreatitis…………………………………………………………………...……… 665
    Eugene P. DiMagno, Peter Layer, and Jonathan E. Clain
  8. The Surgical Treatment of Chronic Pancreatitis……………………………………………. 707
    Charles F. Frey
  9. Diagnosis and Management of Pancreatic Pseudocysts, Pancreatic Ascites,
    And Pancreatic Fistulas
    ……………………………………………………….......….……... 741
    William F. Maule and Howard A. Reber

Endocrine and Exocrine Pancreatic Relationships

  1. Normal Function of the Endocrine Pancreas……………………………………………….. 751
    Murray Korc
  2. The Microvasculature of the Pancreas, With Emphasis on That of the
    Islets of Langerhans: Anatomy and Functional Implications
    ....................................... 759
    S. Bonner- Weir
  3. The Enteroinsular Axis …………………………………………….................................. 769
    W Creutzfeldt and R. Ebert
  4. The Insulin-Acinar Relationship............................................................................... 789
    John A. Williams and Ira D. Goldfine
  5. Endocrine Changes in Pancreatic Insufficiency ...………………………………...………. 803
    Chung Owyang
  6. Pancreas and Islet Transplantation…………………………………………….......……….. 815
    Alan C. Farney and David E. R. Sutherland

Pancreatic Neoplasms

  1. Epidemiology and Etiology of Pancreatic Cancer………………………………………….. 837
    Leon Gordis and Ellen B. Gold
  2. Fine Structure of Human Pancreatic Adenocarcinoma………………………...…...…….. 857
    Horst F. Kern and Hans-Peter Elsässer
  3. Pathology of Nonendocrine Pancreatic Tumors......................................................... 871
    Gunter K1öppel
  4. Exocrine Tumors of the Pancreas…………………………………………….......…..…..... 899
    Isaac Raijman and Bernard Levin
  5. Surgical Management of Exocrine Pancreatic Cancer……………………..……………… 913
    Stanley W Ashley and Howard A. Reber
  6. Gastrinoma........................................................................................................... 931
    Robert T. Jensen and Jerry D. Gardner
  7. Insulinoma…………………………………………………………........……………………... 979
    Richard J. Comi, Phillip Gorden, and John L. Doppman
  8. Miscellaneous Tumors of the Pancreas……………………………...……………………... 997
    P. J. Hammond, J. M. Polak, and S. R. Bloom
  9. Surgery for Endocrine Tumors of the Pancreas………………….......…………………… 1009
    Jeffrey A. Norton, Gerard M. Doherty, and Douglas L. Fraker

Congenital and Hereditary Diseases

  1. Congenital Abnormalities of the Exocrine Pancreas……………………………..........… 1029
    Ivor D. Hill and Emanuel Lebenthal
  2. The Pancreas in Cystic Fibrosis………………………………………………...…..……… 1041
    Emanuel Lebenthal, Aaron Lerner, and David D. K. Rolston
  3. Hereditary Diseases of the Pancreas…………………………………..........……………. 1083
    Aaron Lerner and Emanuel Lebenthal
  4. Hereditary Pancreatitis…………………………………………….............……………….. 1095
    J. Armando Madrazo-de la Garza, Ivor D. Hill,and Emanuel Lebenthal

Imaging of the Pancreas

  1. Imaging of the Pancreas……………..………………………………………………....…… 1103
    Robert L. MacCarty, Ellen M. Ward, J. William Charboneau,
    Patrick F. Sheedy II, and C. Daniel Johnson

Subject Index…………………………………………………………….............................…… 1137