Objectives: Four genome-wide association (GWA) studies have found that variation in a region of strong linkage disequilibrium on the long arm of chromosome 15 (15q24-25.1) containing nicotinic acetylcholine receptor genes contributes to lung cancer risk. Because cigarette smoking is a major risk factor for developing both lung cancer and pancreatic cancer, we hypothesized that variation in this region may also modify individual susceptibility to pancreatic cancer.
Methods: We conducted a case-control study of 523 patients with pathologically confirmed pancreatic adenocarcinoma and 1046 age-, sex-, ethnicity-, and smoking behavior-matched cancer-free controls.
Results: We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
Conclusions: The results of our study suggest that the 2 single nucleotide polymorphisms at 15q25.1 do not modify pancreatic cancer risk.
From the *Department of Epidemiology, The University of Texas MD Anderson Cancer Center; †Program in Human and Molecular Genetics, The University of Texas Graduate School of Biomedical Sciences; Departments of ‡Cancer Genetics, and §Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Received for publication October 13, 2010; accepted March 10, 2011.
Reprints: Marsha L. Frazier, PhD, Department of Epidemiology, Unit 1365, The University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030 (e-mail: firstname.lastname@example.org).
This study was supported by U01 CA111302 (AM Killary), core center support grant CA 16672 (J Mendelsohn), and partial support from CA 74880 and CA 91846 (X Wu) and CA121197 and CA133996 (CI Amos).
The authors do not have conflicts of interest to declare.