Skip Navigation LinksHome > February 2014 - Volume 35 - Issue 2 > Aspirin Intake Correlates With Halted Growth of Sporadic Ves...
Otology & Neurotology:
doi: 10.1097/MAO.0000000000000189
Tumors of the Ear & Cranial Base

Aspirin Intake Correlates With Halted Growth of Sporadic Vestibular Schwannoma In Vivo

Kandathil, Cherian K.*†; Dilwali, Sonam*‡; Wu, Chen-Chi*†; Ibrahimov, Metin*†; McKenna, Michael J.*†; Lee, Hang§; Stankovic, Konstantina M.*†‡

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Abstract

Objective

Given the presence of a pathological immune response in sporadic vestibular schwannoma (sVS), this study aims to explore the roles of aspirin in minimizing sVS growth in vivo.

Study Design

Retrospective case review.

Setting

Tertiary care hospital.

Patients

People diagnosed with sVS and followed at a tertiary referral center by serial magnetic resonance imaging (MRI) for at least 4 months within the period of January 1980 through April 2012.

Main Outcome Measures

Patient use of aspirin and sVS growth rate measured by changes in the largest tumor dimension as noted on serial MRIs

Results

Within a set of 689 cases, 347 were followed by serial MRI scans (50.3%); of the latter, 81 took aspirin, of which, 33 demonstrated sVS growth, and 48 did not. Of the 266 nonaspirin users, 154 demonstrated sVS growth, and 112 did not. A significant inverse association was found among aspirin users and sVS growth (odds ratio [OR]: 0.50, 95% confidence interval [CI]: 0.29–0.85), which was not confounded by age or sex.

Conclusion

Our results suggest a potential therapeutic role of aspirin in inhibiting sVS growth.

Copyright © 2014, Otology & Neurotology, Inc.

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