Adolescent injury and death from motor vehicle crashes continues to be a pressing public health concern. The adolescent age group present a unique challenge in terms of prevention because of their age and thought processes. Over the years, many intervention strategies have emerged to target prevention of motor vehicle crashes in this age group. Some have been more successful than others. When implementing intervention programs for their own communities, nurses must be aware of information regarding adolescent injury prevention in the literature. Reality-based prevention programs appear to be a promising intervention strategy to target motor vehicle crash prevention in adolescents.